1. Activity on bioavailability- based approaches for metals in US and Canada Chris Schlekat (Ni) Eric Van Genderen (Zn) Bob Dwyer (Cu) Bill Stubblefield (OSU) Jasim Chowdhury (ILA) May 24, 2016 Bioavailability Implementation Forum SETAC Europe - Nantes

2. Activity within USA Cu: Implementation of US EPA freshwater Cu BLM-based criteria US EPA marine Cu BLM-based criteria: Scheduled for release in 2016 for public comment Ni/Zn: US EPA Region 5 (Great Lakes) actively considering bioavailability-based approaches for Ni and Zn Zn: State of Utah: Recognition by Utah of the Zn BLM for generating site-specific water quality standards Generic: Movement by US EPA towards development of guidance on implementation “Missing Parameters” Technical Support Document: Use of 10 P for DOC and natural ions within a given ecoregion Combinations often do not occur in nature Still work to do? Influence of US EPA TSD at state level (Oregon) 2

3. Activity within Canada Cu: Cooperative approach with US EPA on updating Water Quality Guideline (WQG) Zn: Canadian Council of Ministries of the Environment (CCME) draft WQG on Zn, which incorporates bioavailability via Multiple Linear Regression Pb: Environment Canada draft WQG on Pb, which incorporates bioavailability via Multiple Linear Regression with the inclusion of Ca, DOC and pH as modifying factors. 3