1. Immune system

3. Human immunodeficiency virus (HIV)

5. HIV replication and transfection cycles

6. How does HIV work?

7. HIV phylogeny and distribution

8. Infection rate is different between strains High, more virulent Low, less virulent

9. Why is the infection rate different between the strains?

11. HIV treatment- AZT AZT Nucleotide Could this treatment work?

12. HIV treatment- AZT What can a prolonged AZT treatment cause?

13. AZT resistance Vs.

14. Pennings et al. 2014

15. AZT resistance Vs. After AZT treatment Are there any resistance strains left?

16. Is there a possible treatment for HIV?

17. HIV resistance Can we treat HIV by blocking CCR5? Δ32 CCR5 frequency

18. Case study: Timothy Brown 29 years old male. HIV positive. Treated with lifesaving anti-retroviral drugs. 11 years later he became sick. Diagnosed with leukemia. Chemo treatments. Leukemia is back. Last chance- stem-cell transplantation Stem-cell donor with Δ32 CCR5 After two stem-cell transplantations- recovery from both leukemia and AIDS!