1. Hyperparathyroidism secondary to renal dysplasia in an English bulldog Diego F Echeverry 1 ; Juanita Otazua¹; Edwin F Buritica 1 1 Clínica de Pequeños Animales, Facultad de Medicina Veterinaria y Zootecnia, Universidad del Tolima, Colombia Fig 3. A. Ultrasonographic appearance of the kidneys revealed irregular shape, poor corticomedullary definition, increased echogenicity and small diameter (2.2cm). B. At necropsy, right kidney (R) was critically reduced in size and left kidney (L) had rough shape. C. Histophatological evaluation revealed pyelonephritis, extensive interstitial fibrosis, glomerular and tubular atrophy and cystic dilation of Bowman's capsule. INTRODUCTION Renal dysplasia is a disorganized renal parenchyma development during embryogenesis. 1 Clinical evidences are those of chronic renal injury. A frequent outcome is the development of secondary hyperparathyroidism 2, which may originate skeletal deformations. 2,3 To the author’s knowledge this is the first case report of secondary hyperparathyroidism associated with renal dysplasia in English Bulldogs. PATIENT DESCRIPTION Age: 4 month-old dog. Breed: English Bulldog. Weight: 5,2 Kg. Clinical manifestations: severe maxillary swelling, gums inflammation, polydipsia, polyuria, and small size for the age. Blood analysis: hypocalcemia (6,42mg/dL), hypercreatinemia (5,26mg/dL), hyperphosphatemia (13,89mg/dL), anemia (VPC 13,1%), and increased serum PTH (810,3pg/dL). Urinalysis: showed low specific gravity (1.006), bacteriuria and pyuria. Fig 1. There was evidence of gums inflammation, oral ulcerations and severe maxillary swelling. Mandible had low density and hardness. CONCLUSIONS The development of secondary hyperparathyroidism and renal dysfunction is very common in renal dysplasia 2 and may originate skeletal deformations that often affects the face bones most prominently specially the maxilla. 2,3 The brown tumor is a localized form of fibrous osteodystrophy observed in these patients due to alterations in the regulation of osteoblast/osteoclast activity. 1 Definitive diagnosis should be made upon demonstration of characteristic lesions in kidneys obtained by necropsy or biopsy. 4 These lesions have been classified as compensatory, inflammatory, and degenerative disorders. 4 Clinical and histopathologic findings in this patient revealed similar lesions to those described previously; 1,3,4 which may suggest that renal dysplasia should be consider as a differential diagnosis of renal diseases in young dogs. REFERENCES: 1. Brum KB, Juliano RS, Souza MA, Fleury LFF, Damasceno, AD. Renal dysplasia in a Boxer dog: case report.. Arq Bras Med Vet Zootec 2008; 1084-1088. 2. Lazaretti P, Kogika MM, Hagiwara MK, et al: Concentração sérica de paratormônio em cães com insuficiência renal crônica. Arq Bras Med Vet Zootec 2006; 58(1): 489-494. Portuguese. 3. Sarkiala EM, Dambach D, Harvey CE: Jaw lesions resulting from renal hyperparathyroidism in a young dog – a case report. J Vet Dent 1994; 11(1): 121-124. 4. Picut CA, Lewis RM: Microscopic features of canine renal dysplasia. Vet Pathol 1987; 24(1): 156-163. October 16-18 Barcelona, Spain A B C L R Fig 2. Maxillaries presented trabecular aspect of brown-reddish color at sagittal cutting.