1. Date of download: 6/27/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Responsiveness to Drug Cues and Natural Rewards in Opiate Addiction: Associations With Later Heroin Use Arch Gen Psychiatry. 2009;66(2):205-212. doi:10.1001/archgenpsychiatry.2008.522 Self-Assessment Manikin (SAM) valence (A) and arousal (B) ratings and corrugator supercilii (C) and zygomaticus major (D) electromyogram reactivity by picture types within baseline groups. Error bars represent 1 SEM. Figure Legend:

2. Date of download: 6/27/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Responsiveness to Drug Cues and Natural Rewards in Opiate Addiction: Associations With Later Heroin Use Arch Gen Psychiatry. 2009;66(2):205-212. doi:10.1001/archgenpsychiatry.2008.522 Postauricular reflex (A, control group [n = 12]; B, opiate-dependent group [n = 23]) and startle-elicited event-related potential (ERP) amplitude (C, control group [n = 19]; D, opiate-dependent group [n = 32]) by picture type within baseline groups. Figure Legend:

3. Date of download: 6/27/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Responsiveness to Drug Cues and Natural Rewards in Opiate Addiction: Associations With Later Heroin Use Arch Gen Psychiatry. 2009;66(2):205-212. doi:10.1001/archgenpsychiatry.2008.522 Scatterplot of standardized residual values for significant baseline predictors of regular heroin use at follow-up. For each variable, a residual score was calculated that reflected the relative response between 2 classes of stimuli. This relative response score is plotted separately for each group (ie, weekly or more frequent heroin use at follow-up [clear circles] vs less than weekly heroin use [black triangles]), within each variable, thereby depicting group differences in their relative response to either drug vs pleasant, drug vs neutral, or pleasant vs neutral stimuli. Figure Legend: