1. CPRIT Prevention Program Overview June 10, 2016 Presented By: Dr. Rebecca Garcia Ms. Ramona Magid

2. CPRIT’s Mission and Action 2 Mission Action Create and expedite innovation in cancer research into prevention and cures Attract, create, or expand research capabilities Create high-quality new jobs in Texas Develop and implement the Texas Cancer Plan Award merit-based, peer reviewed grants to Texas-based entities and institutions for cancer- related research, product development and the delivery of cancer prevention programs and services. ResearchPrevention Product Development

3. The Promise of Prevention  An estimated 39,500 Texans will die from cancer in 2016  ~50% of cancers could be prevented  Example: not smoking could prevent 30% of all cancers and 80% of lung cancers  Every $1 spent through CPRIT for screening/prevention leads to $22 in treatment cost savings, preserved productivity and other economic benefits through earlier detection of cancers. 3

4. Prevention Program Priorities Prioritize populations and geographic areas of greatest need, greatest potential for impact Focus on underserved populations Increase targeting of preventive efforts to areas where significant disparities in cancer incidence or mortality in the state exist Fund evidence-based interventions and their dissemination Support the continuum of primary, secondary and tertiary prevention interventions Principles 2015 Prevention Program Priorities

5. Prevention Program Achievements 2.8 Million Prevention Services to Texans  Over 1.3M education and 1.5M clinical preventive services provided, including: Screening & diagnostics for breast, cervical and colorectal cancer Prevention vaccinations Tobacco cessation services Genetic testing and counseling Survivorship services As of May 2016 5

6. Prevention Program Achievements Counties Served by CPRIT Prevention Projects: 62 Active Projects – May 2016 6 6 Statewide/ Dissemination Projects

7. Areas of Emphasis  All applications responsive to RFA are considered  Areas of Emphasis highlight:  Geographic areas with higher incidence and mortality  Primary cancer prevention  sustainable behavior change & areas not well represented in portfolio (e.g., tobacco cessation, liver cancer prevention)  Screening/early detection  population and geographic disparities  Survivorship and improved quality of life  measurable improvement 7

8. FY17 Prevention Cycle 1 8 Date RFA ReleaseMay 26, 2016 SubmitAug 30, 2016 AwardFeb 15, 2017 Contract start dateMar 1, 2017

9. FY17 Cycle 1 RFAs Evidence-Based Cancer Prevention Services-See, Test & Treat ® Program Up to $25,000 in direct costs for up to 12 months Dissemination of CPRIT-Funded Cancer Control Interventions Up to $300,000 in direct costs for up to 24 months Cancer Prevention Promotion and Navigation to Clinical Services Up to $400,000 in direct costs for up to 36 months Evidence-Based Cancer Prevention Services Up to $1.5 million in direct costs for up to 36 months Competitive Continuation/Expansion for Evidence-Based Prevention Services Up to $1.5 million in direct costs for up to 36 months 9

10. Evidence- Based Cancer Prevention Services-See, Test & Treat ® up to $25K, up to 12 months One-day cervical and breast cancer screening program  Led by pathologist in partnership with others  Same-day or prompt results for participants  Cancer prevention & lifestyle education included Collaboration between CAP Foundation and CPRIT  Processes for both organizations must be followed  CAP Foundation may provide funding for expenses not reimbursable by CPRIT 10

11. Dissemination of CPRIT- Funded Cancer Control Interventions up to $300K, up to 24 months Dissemination of tools/materials/best practices  Package strategies to introduce, modify, and implement successful, previously or currently funded CPRIT projects Dissemination strategies  Two or more active strategies required  Propose approaches for overcoming possible barriers Training/Technical assistance  Identify and guide adopters in developing plans to adapt, refine, and implement projects 11

12. Cancer Prevention Promotion and Navigation to Clinical Services up to $400K, up to 36 months Health promotion, public education, and outreach program  evidence-based strategies designed to change and support personal behavior change Navigation services (required)  assist participants in obtaining the prevention interventions being promoted through navigation. System and process improvement  Improving outreach, delivery, referral processes and systems Outcome Measures  focus of the outcome measures on actions taken as a result of the intervention and navigation services 12

13. Evidence- Based Cancer Prevention Services up to $1.5 M, up to 36 months Deliver at least one service: Primary prevention  e.g., vaccines, risk assessment, counseling and treatment related to healthy diet, tobacco cessation, physical activity, etc. Screening /Early detection  e.g., for breast, cervical, and/or colorectal cancer Survivorship services  e.g., physical rehabilitation/therapy, psychosocial interventions Comprehensive  include education, delivery of service, navigation and system and/or policy improvements  Address access to treatment 18

14. Competitive Continuation/ Expansion up to $1.5M, up to 36 months  Continue or expand only projects previously or currently funded that have demonstrated exemplary success  Closely follow the intent and core elements of current or previous project  build on its initial results and continue to demonstrate ingenuity and resourcefulness  Have feasible plans to integrate some or all of the project into existing and sustainable systems 14

15. Peer Review Evaluation Criteria  Impact and Innovation  Project Strategy and Feasibility  Evaluation  Organizational Qualifications and Capabilities  Integration and Capacity Building 15

16. Multi-Stage Review Process Peer Review Criteria in RFA Based on individual merit, not comparison Programmatic Review Potential for Impact and Return on Investment Geographic distribution Cancer type Type of program 16

17. Prevention Review Council 17 Steve W. Wyatt, DMD, MPH, Prevention Review Council Chair Senior Associate Director and Vice President for Research at UK Center for Clinical and Translational Science and Norton Healthcare Nancy C. Lee, MD, Deputy Assistant Secretary of Health - Women’s Health and the Director of the Office on Women's Health (OWH) at U.S. Department of Health and Human Services Ross C. Brownson, PhD, Professor, Brown School and the Alvin J. Siteman Cancer Center at Washington University

18. Applying for a CPRIT Prevention Grant  Go to https://cpritgrants.org/ to view current RFAshttps://cpritgrants.org/  Go to https://cpritgrants.org/ to submit an applicationhttps://cpritgrants.org/  Application deadline: August 30, 2016 18

19. CPRIT Prevention Team Phone: 512.305.8417 Email: prevention@cprit.state.tx.usprevention@cprit.state.tx.us Web: www.cprit.state.tx.uswww.cprit.state.tx.us 19

20. Discussion What do you see as the biggest cancer disparities/needs in your community/region? What resources are available to address the burden of cancer in your region? What are some of the challenges? 20