1. Coronary Phantom Design for K-edge Angiography John Jorgensen Sarah Pachtman Punam Patel Marcus Spallek Advisor: Dr. Frank Carroll

2. MXI Systems MX 200 –Applications Radiotherapy Crystallography Mammography Pediatrics K-edge Imaging –Angiography??? http://www.onlinetelemedicine.com/html/product/sa m_images/Angiography.jpg

3. Project Background Monochromatic tunable X-ray: –Reduced radiation dose to patient –Reduced contrast agent concentrations K-edge imaging FOR MORE INFO... Free Electron Laser Laboratory  http://www.vanderbilt.edu/fel/ Diagram of MX200’s laser paths and major elements. http://www.mxisystems.com/mx200.html

4. K-edge Effect

5. Project Goals Design a coronary phantom Test contrast agent concentrations –hypersensitivity reaction to iodine (3-12% patients) –current clinical dilution is 1:16 –using monochromatic plain films it is possible to see 1:256 dilutions Determine optimal angle for stereo imaging θ 30” 3” Tan θ = 3/30 = 0.10 θ ~ 6°

6. Solution Description Radio Translucent at 35 keV Flexible material –Fluid perfusion Phantom Size –7.5cm diameter Vasculature –Size Range 5 - 0.5 mm –Coronary arteries on surface –Curved channels –Hollow vessels Finger imaged at 19 keV Finger imaged at 26 keV

7. Phantom Designs Shelley Medical Imaging Technologies www.simutech.com Preliminary Sketch SolidWorks Model

8. Material - ReoFlex ™ Rubber Physical Properties –Flexible cured product –2-component liquid resin system –Room-temperature cure –20 Shore A durometer –60 pli tear strength –200 psi tensile strength –Elongation at Break 1000% www.smooth-on.com

9. Schedule FOR MORE INFO... http://vubme.vuse.vanderbilt.edu/srdesign/2003/group12/NCIIA %20Grant%20Proposal.htm November December January February MarchApril Research Material Testing & Design Manufacturing Testing

10. Current Status Work Completed –Material Selected –SolidWorks Design Completed –ZCORP Contacted (Manufacturer) Rapid Prototyping Machine

11. Future Plans March –Send for Prototype –Start Testing Test Dosimetry for Imaging Test for Optimal Stereo Angle –Start Final Report

12. Team and Resources Advisor: Dr. Frank Carroll, M.D. Monochromatic x-ray machine W.M. Keck Free-electron Laser (FEL) Center at Vanderbilt University Materials and tools provided by BME Department and FEL Center –Polyurethane resins from outside contractors Photograph of device with laser cover removed http://www.vanderbilt.edu/fel/Xray/manuscripts/final%20report%20for%20ONR%20grant%2020021218.doc

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