1. Date of download: 6/28/2016 Copyright © The American College of Cardiology. All rights reserved. From: Trends, Predictors, and Outcomes of Cerebrovascular Events Related to Percutaneous Coronary Intervention: A 16-Year Single-Center Experience J Am Coll Cardiol Intv. 2011;4(4):415-422. doi:10.1016/j.jcin.2010.11.010 Yearly Incidence of PCI-Related CVE Temporal trend analysis indicates no statistically significant change in the incidence of percutaneous coronary intervention (PCI)- related cerebrovascular events (CVEs) between January 1994 and December 2009 after risk adjustment (p = 0.35, dashed lines represent confidence intervals). Figure Legend:

2. Date of download: 6/28/2016 Copyright © The American College of Cardiology. All rights reserved. From: Trends, Predictors, and Outcomes of Cerebrovascular Events Related to Percutaneous Coronary Intervention: A 16-Year Single-Center Experience J Am Coll Cardiol Intv. 2011;4(4):415-422. doi:10.1016/j.jcin.2010.11.010 Characteristics of CVEs Occurring After PCI (A) Symptoms and signs of neurologic event at diagnosis are charted by frequency, with motor weakness and speech impairment being the commonest clinical features at presentation. (B) Vascular distribution of ischemic strokes occurring after PCI as determined by clinical evaluation and brain computed tomography/magnetic resonance imaging. The majority were anterior- circulation events. Of note, a proportion of neurologic events involved both anterior and posterior vascular territories. Abbreviations as in Figure 1. Figure Legend:

3. Date of download: 6/28/2016 Copyright © The American College of Cardiology. All rights reserved. From: Trends, Predictors, and Outcomes of Cerebrovascular Events Related to Percutaneous Coronary Intervention: A 16-Year Single-Center Experience J Am Coll Cardiol Intv. 2011;4(4):415-422. doi:10.1016/j.jcin.2010.11.010 Incidence of CVE After PCI by Age and Previous History of Stroke (A) Risk of PCI-CVE by age. Incidence of CVE increases with age (p < 0.001 for age trend), particularly after age 70 years. (B) Risk of PCI-CVE by age and prior history of stroke. Marked increase in the incidence of CVE in elderly patients with a prior history of stroke. The p values are based on odds ratios employed to describe the magnitude of the association between stroke complications and age and prior history of stroke. Abbreviations as in Figure 1. Figure Legend:

4. Date of download: 6/28/2016 Copyright © The American College of Cardiology. All rights reserved. From: Trends, Predictors, and Outcomes of Cerebrovascular Events Related to Percutaneous Coronary Intervention: A 16-Year Single-Center Experience J Am Coll Cardiol Intv. 2011;4(4):415-422. doi:10.1016/j.jcin.2010.11.010 Long-Term Outcomes After PCI-Related CVE by Kaplan-Meier Analysis (A) Kaplan-Meier estimate for survival. (B) After adjustment for confounding factors, incorporating all predictors with p 24 h) versus transient ischemic attach (TIA) (duration <24 h) indicates no difference in long-term survival between the 2 groups, suggesting that even a transient neurologic event after PCI confers a survival disadvantage. NS = not significant; other abbreviations as in Figure 1. Figure Legend: