1. Peter Konrad, MD PhD Director, Functional Neurosurgery Vanderbilt University #12 - Konrad

2. Consulting: Medtronic Neurological; FHC Inc. Fiduciary Position: CMO – Neurotargeting LLC Will not discuss off label use of approved FDA products #12 - Konrad

3. Sensing System Processing / Energy Delivery System Neurological Device Platform Technology #12 - Konrad

4.  Goals: Restore Useful Sensory-Motor Control  Methods:  Extract Control Information  Insert Sensory Feedback  Information Processing Stroke SCI Amputation ALS Motor Signal Extraction Sensory Signal Insertion #12 - Konrad

6. Hochberg et al. Nature 442: 164-171, 2006 #12 - Konrad

12. Examine alternative user command interfaces -- based on facial and neck EMG signals, as well as head orientation. Courtesy: Dr. Hunter Peckham #12 - Konrad

13. opening: brachioradialis | closing: trapezius EMG EMG based Control – hand grasp Intramuscular electrode Courtesy: Dr. Hunter Peckham #12 - Konrad

14. Instead of stimulating at proximal to muscles, why not stimulate upstream using a multi-electrode cuff? R. Kirsch, Case Western Reserve University / VA Cuff electrode: 4 contacts Human peripheral nerve Cuff Leads #12 - Konrad

16.  Approved: signal insertion (+ a few signal extraction) implants  ? Signal processing needs  ? Body LAN  Can we take cues from computer / communications industry? Stroke SCI Amputation ALS Motor Signal Extraction Sensory Signal Insertion #12 - Konrad

17. Sensing System Processing / Energy Delivery System Neurological Device Platform Technology #12 - Konrad