1. MARUZEN PHARMACEUTICALS CO., LTD. POMEGRANATE EXTRACT BG30 (ZAKURO) Unwanted Body Hair Growth Deaccelerator 090303

2. POMEGRANATE / ZAKURO MARUZEN PHARMACEUTICALS CO., LTD. Deaccelerates unwanted body hair growth Safety material from its food experience Recommended for sensitive skin after shaving for self body care products for esthetic salon products POMEGRANATE EXTRACT BG30 Zakuro

3. Body Hair Treatment MARUZEN PHARMACEUTICALS CO., LTD. Unwanted body hair (facial vellus hair, armpit, arm, lower leg) Treatment 1: Mechanical treatment (Shaver, depilatory device) 2:Chemical treatment (Depilatory agent) Skin irritation Repeated treatment of body hair is required as these treatments do not inhibit body hair growth. Body Hair Treatment Natural plant extracts with safety and efficacy of deaccelerating unwanted hair growth speed is required for after body hair treatment. Wax Gel Tape Shaver

4. Self Body Care Products MARUZEN PHARMACEUTICALS CO., LTD. Body lotion Body lotion Facial gel Many self body care products focus on unwanted body hair have been launched.

5. Botanical information Name; Punica granatum L. Family name; Punicaceae English name; Pomegranate Japanese name; 石榴 (Zakuro) Part used; Fruit peel Native to Southeast Asia to East Asia. POMEGRANATE EXTRACT BG30 Product information INCI NAMEComposition PUNICA GRANATUM PERICARP EXTRACT BUTYLENE GLYCOL WATER 0.50 ％ 29.85 ％ 69.65 ％ MARUZEN PHARMACEUTICALS CO., LTD. JSQI status : N.A.

6. Symbolism of beauty It is well known that legendary beauties such as Cleopatra and Chinese imperial consort, Yang Guifei liked to eat pomegranate for maintain their beauty. Even today, people connect pomegranate with these legendary beauties. That is why many feminine and beauty image foods and drinks using pomegranate have been launched. POMEGRANATE / ZAKURO Antony and Cleopatra, by Lawrence Alma-Tadema Four Great Chinese Beauties MARUZEN PHARMACEUTICALS CO., LTD. Popularity in Asia From ancient times, pomegranate has attracted widespread popularity as for a beauty-enhancing food. It is eaten in a many kinds of ways, as a raw fruit, jam, sweets, juice in and cocktails in many countries.

7. Subject : 5 healthy male and female volunteers (Average 32.8 years old) Test site : Lower legs Test sample : Cream containing 2% POMEGRANATE EXTRACT BG30 (Placebo: cream without POMEGRANATE EXTRACT BG30) Test method: Day 0 : 1 st shaving (shave lower legs) Day 7 : 1 st measurement (measure the length of the hair to check the test site hair is in aganen stage) No test sample application for the first 7 days. Day 7 : 2 nd shaving (shave at the same site of 1 st shaving) Start the test sample application twice daily for 7 days. Day 14 : 2 nd measurement (Measure the length of hair in anagen stage by microscope.) 0 No application 14 Days 1 st shaving 7 Application 2 nd shaving 1 st measurement2 nd measurement Clinical Study Deaccelerating Effect of Body Hair Growth MARUZEN PHARMACEUTICALS CO., LTD.

8. Cream formulation Placebo cream contains 2% of 30vol% 1,3-butylene glycol instead of 2% POMEGRANATE EXTRACT BG30. Clinical Study Deaccelerating Effect of Body Hair Growth MARUZEN PHARMACEUTICALS CO., LTD.

9. Placebo 2% POMEGRANATE EX.BG30 Cream Day 14 After application Day 7 Before application Clinical Study Deaccelerating Effect of Body Hair Growth MARUZEN PHARMACEUTICALS CO., LTD.

10. Day 7 before application Day 14 after application 50 75 100 125 Hair growth (%) Placebo POMEGRANA EXTRACT BG30 deaccelerated the body hair growth at an average 7.4 %. Clinical Study Deaccelerating Effect of Body Hair Growth 50 75 100 125 Hair growth (%) 2% POMEGRANATE EX. BG30 Cream Day 7 before application Day 14 after application

11. IC50 : 191μg/mL 0 20 40 60 80 100 Control2004001000 TSR activity (%) Pomegranate extract (solid) (μg/mL) (3.8% as product) As POMEGRANATE EXTRACT BG30 showed an inhibition effect of Testosterone 5α-reductase activity dose dependently, it is expected to inhibit the male hormone activity and the unwanted body hair growth. POMEGRANATE / ZAKURO In-vitro Test – 1 Inhibition Effect of Testosterone 5α-reductase Activity MARUZEN PHARMACEUTICALS CO., LTD.

12. Inhibition (%) 0 25 50 75 100 01.566.2525.050.0 Pomegrana Extract as extract solid (μg/mL) 1% as product Dermal papilla cell proliferation is involved in increasing the size of dermal papilla cell itself and thickening the hair. As POMEGRANATE EXTRACT BG30 inhibited its proliferation dose-dependently, it is expected to reduce the thickness of body hair and make it less visible. Dermal papilla cell POMEGRANATE / ZAKURO In-vitro Test – 2 Inhibition Effect of Dermal Papilla Cell Proliferation MARUZEN PHARMACEUTICALS CO., LTD.

13. To offer you the vitality of nature to enhance health, beauty, and humanity Thank you for your attention. POMEGRANATE EXTRACT BG30