1. Date of download: 6/29/2016 Copyright © 2016 SPIE. All rights reserved. The schematic of the rotational probe in noncontact diffuse correlation tomography (ncDCT) system. (a) A motorized rotational stage was used to drive the ncDCT probe to scan over a region of interest (ROI) on the breast surface. The rotation axis was aligned through the nipple. (b) During ncDCT probe scanning, source and detector rays were adjusted to be perpendicular to the breast surface over the ROI. The two source pairs at first and last scanning steps were marked using a mark pen. (c) Fifteen detector fibers and two source fibers were projected on the breast surface with the S–D separations spanning from 10 to 30 mm. Figure Legend: From: Noncontact diffuse correlation tomography of human breast tumor J. Biomed. Opt. 2015;20(8):086003. doi:10.1117/1.JBO.20.8.086003

2. Date of download: 6/29/2016 Copyright © 2016 SPIE. All rights reserved. Flowchart outlining the sequence and commands used in the modified NIRFAST to generate a forward model for ncDCT. Figure Legend: From: Noncontact diffuse correlation tomography of human breast tumor J. Biomed. Opt. 2015;20(8):086003. doi:10.1117/1.JBO.20.8.086003

3. Date of download: 6/29/2016 Copyright © 2016 SPIE. All rights reserved. Flowchart outlining the sequence and commands used in the modified NIRFAST to solve diffuse correlation tomography inverse problem. Figure Legend: From: Noncontact diffuse correlation tomography of human breast tumor J. Biomed. Opt. 2015;20(8):086003. doi:10.1117/1.JBO.20.8.086003

4. Date of download: 6/29/2016 Copyright © 2016 SPIE. All rights reserved. Recovery of anomaly blood flow contrasts inside the slab-shaped and breast-shaped volume meshes. A sphere anomaly with a diameter of 10 mm and 10-fold flow contrast was placed at 7 mm beneath the surface of background tissue volumes. (a) and (e) show the original assigned anomalies inside the volume meshes with sources and detectors aligned on the mesh surfaces; (b) and (f) show the reconstructed anomalies with full-width at half-maximum (FWHM) thresholds; (c) and (g) show the two-dimensional (2-D) cross-section views of original flow contrast distributions through the anomaly centers; (d) and (h) show the 2-D cross-section views of reconstructed flow contrast distributions. Figure Legend: From: Noncontact diffuse correlation tomography of human breast tumor J. Biomed. Opt. 2015;20(8):086003. doi:10.1117/1.JBO.20.8.086003

5. Date of download: 6/29/2016 Copyright © 2016 SPIE. All rights reserved. Evaluation of reconstruction accuracy of ncDCT in the breast-shaped volume mesh. (a) and (b) show the center location and deviation of the reconstructed anomaly at different depths; (c) shows the percentage deviations of anomaly peak and average blood flow index (BFI) contrasts at different depths; (d) and (e) show the linear relationships between the assigned and reconstructed peak and average BFI contrasts at different depths. Figure Legend: From: Noncontact diffuse correlation tomography of human breast tumor J. Biomed. Opt. 2015;20(8):086003. doi:10.1117/1.JBO.20.8.086003

6. Date of download: 6/29/2016 Copyright © 2016 SPIE. All rights reserved. Noise influence on imaging accuracy of ncDCT. An anomaly was placed beneath the surface of the breast-shaped mesh with varied central depths from 7 to 15 mm. (a) and (b) show the center location and deviation of the anomaly at different depths, reconstructed with or without noise. (c) and (d) show percentage deviations of anomaly peak and average BFI contrasts at different depths, reconstructed with or without noise. Figure Legend: From: Noncontact diffuse correlation tomography of human breast tumor J. Biomed. Opt. 2015;20(8):086003. doi:10.1117/1.JBO.20.8.086003

7. Date of download: 6/29/2016 Copyright © 2016 SPIE. All rights reserved. Comparison of anomaly reconstructions without and with a priori structural information. The top [(a)–(e)] and bottom [(f)–(j)] panels show the reconstructed flow contrast distributions of an anomaly (assigned a 10-fold flow contrast) located at 7 and 15 mm central depths, respectively. (a) and (f) show reconstructed results without the a priori structural knowledge of the anomaly; (b) and (g) show the reconstructed results with the a priori structural knowledge; (c) and (h) show the reconstructed results without the a priori structural knowledge and with noise. (d) and (i) show the reconstructed results with the a priori knowledge information and with noise. The flow contrast profiles crossing the yellow lines are shown in (e) and (j). Figure Legend: From: Noncontact diffuse correlation tomography of human breast tumor J. Biomed. Opt. 2015;20(8):086003. doi:10.1117/1.JBO.20.8.086003

8. Date of download: 6/29/2016 Copyright © 2016 SPIE. All rights reserved. Clinical examples of two low-grade carcinomas in situ. (a) Patient 1 (P1) ultrasound image taken from radio direction shows a 10.2×6.65 mm2 oval mass (inside the yellow dashed circle) with circumscribed margins parallel to the skin. The mass center is located at 19.2 mm beneath the skin surface. A core biopsy revealed a ductal papilloma with low-grade ductal adenocarcinoma in situ. (d) Patient 2 (P2) ultrasound image shows an 8.5×3.5 mm2 mass (inside the yellow dashed circle), located at 13.3 mm beneath the skin surface. A core biopsy revealed atypical ductal hyperplasia and low-grade carcinoma in situ. (b) and (e) show the reconstructed three-dimensional (3-D) tumor blood flow contrasts with FWHM thresholds for P1 and P2, respectively. The backgrounds are presented with 30% transparency of the original color clarity. For the comparison of ultrasound and ncDCT results, an ultrasound imaging plane along the transducer line and across the overlapped two specific sources (S1 and S2) is presented in the 3-D reconstructed image. (c) and (f) show the cross-section views of tumor flow contrast images through the ultrasound imaging planes, which can be directly compared to the 2-D ultrasound tumor images [(a) and (d)], respectively. Figure Legend: From: Noncontact diffuse correlation tomography of human breast tumor J. Biomed. Opt. 2015;20(8):086003. doi:10.1117/1.JBO.20.8.086003