1. Rede Nacional de Ressonância Magnética Nuclear Portuguese NMR Network At the Service of Excellence in Science

2. The PT NMR network Objectives Management and Accessibility Activities and Scientific Impact Perspectives OUTLINE

3. The PTNMR provides a service in NMR spectroscopy to the scientific community and companies. This service includes access to modern NMR equipment, service spectra for occasional users, training in NMR methods for regular users, consultation and collaboration on experimental design, data collection and analysis.

4. December 20 th 2006 Delivery of the 800 MHz magnet

5. CENTRO DE RESSONÂNCIA MAGNÉTICA ANTÓNIO XAVIER July 2007

6. 400 500 800 300 400 500 300 400 600 400 First generation of equipment acquired by the PTNMR 13 NMR spectrometers 8 Institutions € 6.5 Million investment 1  800 MHz 2  600 MHz ( 1 with cryoprobe ) 3  500 MHz 5  400 MHz 2  300 MHz

7. 800 600 High-Field Service in the National NMR Network 600 Coimbra Oeiras Monte de Caparica

8. 2010 : PTNMR comprises 19 spectrometers 400UMinho 400; 500 UAveiro UAveiro 400; 500; 600 UCoimbra 500; 400; 300 IST 800; 500; 500; 400; 300 ITQB 600; 400; 300 FCT- UNL 400 MHz UMadeira UMadeira 400 UPorto UPorto Aveiro and Coimbra (Chem Dep) join the Network; older equipments were integrated

9. Low field Spectrometers – (300, 400 and 500 MHz) Routine analysis and support of internal analytical services of the host institutions for research and teaching Analytical services to industry The PT NMR Network Highly specialized, research & development oriented, essential for the competiveness of the Portuguese scientific community in advanced human resources formation (Masters, PhD, post- docs) and fund raising. High field Spectrometers – (600 and 800 MHz)

10. The PT NMR Network Routine analysis (liquid NMR) CERMAX ITQB REQUIMTE FCT-UNL UMadeira UPorto IST-UTL CNC UCoimbra UMinho UAveiro Routine analysis (solid NMR) CENIMAT FCT-UNL FCT UCoimbra FCT UCoimbra

11. Specific expertise within the Network Material Sciences Micro imaging Structural Biology Small molecules Small molecules In vivo NMR Metabol omics UAveiro CENIMAT – FCT/UNL UCoimbra CERMAX- ITQB REQUIMTE – FCT/UNL The PT NMR Network

12. Objectives of the PT NMR Network Scientific/Academic To promote the development of NMR and the advanced formation of human resources in Portugal To provide an integrated access to state-of-the-art NMR techniques and services to the scientific community and industry To contribute to the internationalization of the Portuguese science Management To promote implementation of integrated and good management practices in the host institutions To take care of the maintenance and funding of the infrastructure

13. Management and Accessibility Coordinator Management Committee (one per unit + 1 FCT-MCTES) Management Committee (one per unit + 1 FCT-MCTES) Unit Manager International Scientific Advisory Committee Users Support Staff Management and accessibility according to a policy agreed between all partners and FCT-MCTES – Management Protocol Project Evaluation Panel (mainly for high field spectrometers)

14. Management and Accessibility All Information concerning equipment, services, management and accessibility available on-line at two levels: 1 - PtNMR Network webpage: http://ptnmr.dq.ua.pt Characterization and location of the network units, management model, services and expertise, contacts, network Activities (prizes, courses, conferences, etc) 2 – Individual Network Unit webpages Characterization of the network unit, type of equipment services and expertise, contacts, how to request spectrometer time, calendar of spectrometers occupancy, etc

19. Booking Instrument Time

20. Accessibility

21. Activities and Scientific Impact Networking activities: First Meeting of the National NMR Network

22. Activities and Scientific Impact Networking activities -70 % of high field (800 + 600 MHz) spectrometer time allocated to external services → promotion of researchers mobility within the network - Training: specialized and beginner courses Beginner courses – held annually Practical NMR course at CERMAX-ITQB, held annually since 2008 NMR: From theory to practice (FCT-UNL) held annually since 2007 Advanced courses – different specialized topics Ligand based NMR interaction studies (FCT-UNL) – March 2010 CCPNMR10 analysis (IGC/CERMAX) – June 2010

23. Networking activities - Support to other advanced formation actions within PhD programs and International Summer Schools: - Summer School on “Proteins in Proteomics” (FCT-UNL) - Modern Methods of Structure elucidation (IST-UNL) - Biomedical Magnetic Resonance: Molecular imaging and Metabolism (CNC Doctoral Program – Coimbra) - 1 st PT NMR Meeting – Meeting on Biomolecular NMR – December 2009, ITQB Activities and Scientific Impact

24. External Services Services to other Universities and industry is still a minor percentage of the spectrometer allocation time. Main Service Providers Activities and Scientific Impact

25. Scientific Impact in numbers (2008-2009) -Publications: Book Chapters: 6 Publications with relevant NMR contribution 2008 – 171 2009 – 131 (until August 2009) - Projects (with relevant NMR contribution): 97 (1 EU COST, 1 Marie Curie)

26. -Support to PhD and post-doctoral fellows: PhD students: more than 100 (strongly NMR dependent work program) 10 completed PhDs in the NMR field Post-Doctoral: 40 fellowships Scientific Impact in numbers (2008-2009)

27. Continue to support the scientific and Academic community by providing services and education Establish partnerships and exchange programs with other related European Networks Contribute to increase the awareness of the potential of the PTNMR infrastructure in terms of service and contribution to the internationalization of the Portuguese R&D in Academia and Industry To ensure an integrated maintenance and updating plan of the infrastructure Perspectives

28. Contrato-Programa 2010-2012 Rede Nacional RMN/FCT-MCTES ca 85 % funding of global operational costs, including: - Maintenance (contracts and consumables) - Human Resources Fundamental Tool to Keep the Network Running Perspectives

30. 200820072006 EXECUÇÃO INSTALAÇÃO OPTIMIZAÇÃO REDE NACIONAL DE NMR 2005 CONSTRUÇÃO