1. Silicon Biotechnology Biosilica spicules from sponge Tethya aurantia Protein from central filament: 75% similarity to human Cathepsin L Prof. Dan Morse, UCSB K.Shimizu et al., Proc. Natl. Acad. Sci., USA 95, 6234 (1998)

2. Silicon Biotechnology: Applications Structure-Directing Catalysis: Coherent, stereo-regular silicon-based polymers for improved optoelectronic performance Writing nanoscale features of silica and other metal-oxides on silicon Biosensors : Integrated optoelectronic biochips Enzymatic Synthesis : New routes to silicon-based monomers and polymers New materials with advantageous new properties

3. Acknowledgments Chmelka Group Samuel BishopDr. Hideki Maekawa Sean ChristiansenDr. Ricardo Mallavaia Ryan Hayward Heather Maynard Dr. Niklas HedinNicholas Melosh Howard HuangVikas Mittal Michael MannChris Steinbeck Professor Galen Stucky, Chemistry Dr. Dongyuan ZhaoMichael Bartl Dr. Peidong YangBrian Scott Dr. Gernot Wirnsberger Professor Mark Brzezinski, Marine Biology Dr. Yolanda del AmoMark Demarest Professor Daniel Morse, Molecular Biology Professor Alan Heeger, Physics

4. Silicatein Nature’s Structure-Directing Catalyst Polymerizes Silica, Methyl- and Phenyl-silsesquioxanes