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RNA polymerase II kinetics in polo polyadenylation signal selection by Pedro A B Pinto, Telmo Henriques, Marta O Freitas, Torcato Martins, Rita G Domingues, Paulina S Wyrzykowska, Paula A Coelho, Alexandre M Carmo, Claudio E Sunkel, Nicholas J Proudfoot, and Alexandra Moreira EMBO J. Volume 30(12):2431-2444 June 15, 2011 ©2011 by European Molecular Biology Organization
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RNA Pol II kinetics with a slower transcription elongation rate affects pA site selection. Pedro A B Pinto et al. EMBO J. 2011;30:2431-2444 ©2011 by European Molecular Biology Organization
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Deletion of polo distal pA2 signal causes abnormal formation of the fly abdomen. Pedro A B Pinto et al. EMBO J. 2011;30:2431-2444 ©2011 by European Molecular Biology Organization
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ΔpA2 transgene causes a failure in abdominal histoblasts proliferation and produces lower Polo protein levels in histoblasts. Pedro A B Pinto et al. EMBO J. 2011;30:2431-2444 ©2011 by European Molecular Biology Organization
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polo pA2 RNA is stable and the corresponding 3′UTR confers higher translability to a reporter gene in Drosophila cells. Pedro A B Pinto et al. EMBO J. 2011;30:2431-2444 ©2011 by European Molecular Biology Organization
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Overexpression of polo leads to an increase in pA1 utilization and a reduction in GFP–Polo protein levels. Pedro A B Pinto et al. EMBO J. 2011;30:2431-2444 ©2011 by European Molecular Biology Organization
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Proposed working model for the role of Pol II kinetics on pA site selection. Pedro A B Pinto et al. EMBO J. 2011;30:2431-2444 ©2011 by European Molecular Biology Organization
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