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Published byWinfred Parsons Modified over 8 years ago
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Overview of glucose metabolism © Michael Palmer 2014
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The place of glycolysis in glucose degradation © Michael Palmer 2014
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Alternate structures of D-glucose © Michael Palmer 2014
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Reactions in glycolysis © Michael Palmer 2014
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The phosphate groups in ATP are shielded from nucleophilic attack © Michael Palmer 2014
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The catalytic mechanism of hexokinase © Michael Palmer 2014
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Hexokinase envelopes its substrates to prevent ATP hydrolysis © Michael Palmer 2014
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Phosphohexose isomerase performs acid-base catalysis © Michael Palmer 2014
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Glyceraldehyde-3-phosphate dehydrogenase carries out covalent catalysis © Michael Palmer 2014
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Structure and redox chemistry of NAD + and NADP + © Michael Palmer 2014
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Pyruvate Kinase © Michael Palmer 2014
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Energy-rich functional groups in substrates of glycolysis ● the enolphosphate in PEP ● the carboxyphosphate in 1,3-bisphosphoglycerate ● the thioester in the active site of glyceraldehyde-3- dehydrogenase
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Regeneration of cytosolic NAD + under aerobic conditions © Michael Palmer 2014
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Under anaerobic conditions, NAD + is regenerated by lactate dehydrogenase © Michael Palmer 2014
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Ethanolic fermentation in yeast serves a dual purpose © Michael Palmer 2014
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Kinetics of glucose transport by facilitated diffusion © Michael Palmer 2014
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GLUT transporters in different tissues vary in their affinity for glucose © Michael Palmer 2014
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Reaction velocities of hexokinase and glucokinase © Michael Palmer 2014
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