Presentation is loading. Please wait.

Presentation is loading. Please wait.

Overview of glucose metabolism © Michael Palmer 2014.

Similar presentations


Presentation on theme: "Overview of glucose metabolism © Michael Palmer 2014."— Presentation transcript:

1 Overview of glucose metabolism © Michael Palmer 2014

2 The place of glycolysis in glucose degradation © Michael Palmer 2014

3 Alternate structures of D-glucose © Michael Palmer 2014

4 Reactions in glycolysis © Michael Palmer 2014

5 The phosphate groups in ATP are shielded from nucleophilic attack © Michael Palmer 2014

6 The catalytic mechanism of hexokinase © Michael Palmer 2014

7 Hexokinase envelopes its substrates to prevent ATP hydrolysis © Michael Palmer 2014

8 Phosphohexose isomerase performs acid-base catalysis © Michael Palmer 2014

9 Glyceraldehyde-3-phosphate dehydrogenase carries out covalent catalysis © Michael Palmer 2014

10 Structure and redox chemistry of NAD + and NADP + © Michael Palmer 2014

11 Pyruvate Kinase © Michael Palmer 2014

12 Energy-rich functional groups in substrates of glycolysis ● the enolphosphate in PEP ● the carboxyphosphate in 1,3-bisphosphoglycerate ● the thioester in the active site of glyceraldehyde-3- dehydrogenase

13 Regeneration of cytosolic NAD + under aerobic conditions © Michael Palmer 2014

14 Under anaerobic conditions, NAD + is regenerated by lactate dehydrogenase © Michael Palmer 2014

15 Ethanolic fermentation in yeast serves a dual purpose © Michael Palmer 2014

16 Kinetics of glucose transport by facilitated diffusion © Michael Palmer 2014

17 GLUT transporters in different tissues vary in their affinity for glucose © Michael Palmer 2014

18 Reaction velocities of hexokinase and glucokinase © Michael Palmer 2014


Download ppt "Overview of glucose metabolism © Michael Palmer 2014."

Similar presentations


Ads by Google