1. Tissue Repair
Chapter 3
Ms. Figueroa

2. Objectives Describe the steps in tissue repair
Explain the difference in repair depending upon the type of tissue injured
Define wound healing

3. Introduction (p )
The body has many defenses for protecting itself from pathogens and injuries: skin, cilia, and the acid in your stomach are just a few.
When injury occurs, it stimulates an inflammatory and immune responses, which begins immediately.
Inflammation- generalized body response to prevent further injury.
Immune response- extremely specific to the body region and mounts a vigorous attack

4. Types of Wound Healing
There are two main ways: regeneration and fibrosis
Regeneration- replacement of destroyed tissue by the same kind of cells
Fibrosis- repair done by dense fibrous connective tissue that results in scar tissue. Depends upon:
a. Type of tissue damaged
b. The severity of injury
In general, clean cuts heal more successfully than ragged cuts

5. Stages of Wound Healing
Inflammation
Inflammatory chemicals make the capillaries permeable
This allows clotting proteins and other substances from the bloodstream to flood the injured area.
A clot forms, stopping blood loss and holding the edges of the wound together.
The air dries the clot, hardens, and forms a scab

6. Granulation
Granulation tissue forms (pink, delicate)
Tissue contains phagocytes: dispose of the blood clot
Connective tissue cells produce the building blocks of collagen fibers
Permanently bridges the gap between the torn tissue

8. Regeneration
Surface epithelium begins to regenerate
It makes its way across the scab causing it fall off
The new repaired area is referred to as a scar.
A scar can be visible depending upon the deepness/severity of the original injury

9. Diabetic Wound Healing= Much Slower Process
Normal healing process