1. © Copyright 2004 Frost & Sullivan. All Rights Reserved. Drugs in The Pipeline – An R&D Analysis Functional Genomics Provides Easy Target Identification and Drives Drug Discovery Technical Insights Group “As opposed to conventional sequence homology, functional genomics adds structure- based predictions to locate gene sequences with assigned and confirmed functions.”

2. © Copyright 2004 Frost & Sullivan. All Rights Reserved. Key Features Frost & Sullivan Provides: Synopsis of recent developments in the field of drug discovery A gist of the emerging technologies and applications Analysis of technological trends that might affect market size and growth A summary of key patents to give one insight into notable activity and important players Reports on technology drivers as well as obstacles in the way of commercial success

3. © Copyright 2004 Frost & Sullivan. All Rights Reserved. What We Offer Global Coverage: U.S., Europe, Japan, and Asia Proven methodology encompassing extensive primary and secondary data and research Focused information and strategies that cover business and technology issues Profiles of leading companies in the forefront of drug discovery Analyst insights into ‘hot topics’ and emerging applications in the field of drug discovery

4. © Copyright 2004 Frost & Sullivan. All Rights Reserved. Who Will Benefit? Current Technology Participants Find out how you compare to the competition Assess current and future drivers and restraints Determine and exploit market share opportunities Find the best candidates for licensing agreements and partnerships New Entrants Analyze challenges Calculate timescales for strategy implementation Position yourself to capitalize on the emerging applications Uncover the best players to assist you with developing your technology

5. © Copyright 2004 Frost & Sullivan. All Rights Reserved. Who Will Benefit? (Cont’d) Investment Community Analyze long-term strategies of the pharmaceuticals market Identify participants that will lead the market development Assess attractiveness of investing in the pharmaceuticals market

6. © Copyright 2004 Frost & Sullivan. All Rights Reserved. AGY Therapeutics Avanir Pharmaceutical, USA Aventis AVI BioPharma Binotech, USA deCODE genetics Eisai Eli Lilly & Co. Forrest Laboratories GenVec, Inc. Introgen Therapeutics, Inc. Isis Pharmaceuticals Key Market Participants Millenium Pharmaceuticals Nexia Biotechnologies, Inc. Novartis Organon, The Netherlands OSI Pharmaceutical, USA Pfizer, Japan Pharmaceutical Profiles, UK PLIVA d.d Solubest, Israel Targacept Xencor Yamanouchi

7. © Copyright 2004 Frost & Sullivan. All Rights Reserved.  Call toll free: 877 GO FROST (877.463.7876)  Fax toll free: 888.690.3329  E-mail: technicalinsights@frost.com  Visit: www.frost.com For More Information