1. Remyelination Therapy for Multiple Sclerosis By Jordan Burnett With Dr. Gullo https://uchicagomed.files.wordpress.com/2015/03/multiple_s clerosis.jpg

2. Multiple Sclerosis Past Treatments Intro to Remyelination Remyelinating drug trials Why I chose this project – Father has Primary-progressive MS – Interested in the developing treatments Overview and Inspiration

3. An immune- mediated/autoimmune disease Immune system attacks myelin Four types: 1. Relapsing-remitting 2. Secondary-progressive 3. Primary-progressive 4. Progressive-relapsing Multiple Sclerosis https://bionews-tx.com/wp- content/uploads/2014/02/Multiple-Sclerosis-myelin.jpg

4. Slow disease progression – Immune modulating drugs o More beneficial in Relapsing-remitting Treat relapses Manage symptoms Rehabilitate functioning Past Treatments

5. https://www.youtube.com/watch?v=KUvDeQSiIjw& app=desktop Remyelination

6. Generation of new myelin sheaths around axons in adult brains Two major steps 1. Oligodendrocyte Progenitor Cells (OPCs) colonize lesions 2. OPCs differentiate into myelinating oligodendrocytes Remyelination

7. Remyelinating drugs: – Anti-LINGO-1 – rHIgM22 – Anti-SEMA4D Many more in trial Remyelination http://vertassets.blob.core.windows.net/image/c0b 60777/c0b60777-3c6a-11d4-8c48- 009027de0829/bio1.jpg

8. Is remyelination a feasible treatment for MS? What are the drugs in trial for remyelination? – How were these drug targets discovered? – What are the drugs’ mechanisms? Research Questions

9. http://www.acorda.com/products/research-development/rhigm22 http://multiple-sclerosis-research.blogspot.com/2014/09/anti- sema4d-antibody-targeting-ms.html Chari, Divya M. “Remyelination in Multiple Sclerosis”. International Review of Neurobiology. 79 (2007): 589-620. Web. 14 Feb. 2016. http://multiplesclerosisnewstoday.com/2015/02/06/acorda- announces-phase-1-results-for-remyelinating-antibody-in-multiple- sclerosis/ http://www.nationalmssociety.org http://www.nytimes.com/2008/03/04/health/04brod.html?_r=0 Works Cited