1. Aim: How does DNA replicate itself?

2. DNA Structure Review What is DNA composed of? Nucleotides 4 types Adenine Thymine Guanine Cytosine Deoxyribose

3. How do the Bases Pair Up? All Teachers Go Crazy H Bonds

4. DNA Structure What shape is this? Double-Helix What scientists shared the Nobel Prize for their work on DNA? Maurice Wilkins Watson & Crick Rosalind Franklin

5. What Process is Taking Place Here? Cell Division Why do our cells need to divide? 2-GROWTH 1-REPAIR

6. What does the DNA do before a cell divides? Genetic Information (DNA) DNA must replicate before a cell divides Why must DNA replicate itself? DNA is the “Blueprint” for all cell activities. Each cell needs the entire “Blue- print” to function properly.

7. DNA Replication (Hint) Replicate means to make a copy What does REPLICATE mean?

8. What do we get when DNA replicates? DNA Replication + Two New DNA Molecules

9. What are the Steps of DNA Replication? Bonds Broken Step 1: Bonds between the bases are broken and the DNA Molecule is “Unzipped” Enzymes G C C G T A A T T A 2 Separate Strands G - C C - G T - A A - T T - A DNA Molecule

10. Step 1: “Unzipping” the DNA The bonds between the bases are broken and the DNA molecule is “Unzipped”

11. Each strand is a Template for base pairing What are the Steps of DNA Replication? Step 2: Individual bases find their “match” on each single strand of DNA G C C G T A A T T A 2 Separate Strands “Base Pairing” C G A T A CGATACGATA G C T A T Enzymes DNA Polymerase GCTATGCTAT

12. What are the Steps of DNA Replication? Step 3: Bonds between the bases are formed G C C G T A A T T A Bonds Formed G - C C - G T - A A - T T - A

13. DNA Replication G - C C - G T - A A - T T - A DNA Molecule G C C G T A A T T A 2 Separate Strands G - C C - G T - A A - T T - A Bonds Broken Base Pairing What is formed? 2 Identical DNA Molecules

14. What Process is this? DNA Replication Each strand serves as a Template

15. “Extra Material” Summary Questions 1)Do you think DNA Replication is an accurate process? Why? 2)What do you think would happen if DNA did not accurately replicate? 3)What are some of the consequences? 4)DNA Replication AnimationDNA Replication Animation