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Mutations in RNAs of both ribosomal subunits cause defects in translation termination by Alexey L. Arkov, David V. Freistroffer, Måns Ehrenberg, and Emanuel.

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Presentation on theme: "Mutations in RNAs of both ribosomal subunits cause defects in translation termination by Alexey L. Arkov, David V. Freistroffer, Måns Ehrenberg, and Emanuel."— Presentation transcript:

1 Mutations in RNAs of both ribosomal subunits cause defects in translation termination by Alexey L. Arkov, David V. Freistroffer, Måns Ehrenberg, and Emanuel J. Murgola EMBO J. Volume 17(5):1507-1514 March 2, 1998 ©1998 by European Molecular Biology Organization

2 Nature and location of the mutations, in rRNAs from ribosomal subunits, analyzed in this study. Alexey L. Arkov et al. EMBO J. 1998;17:1507-1514 ©1998 by European Molecular Biology Organization

3 Diagram of the essential features of the realistic in vitro termination system used in this study. Alexey L. Arkov et al. EMBO J. 1998;17:1507-1514 ©1998 by European Molecular Biology Organization

4 Hydrolysis of peptidyl ‐ tRNA determined with ribosomes isolated from mutant and wild ‐ type strains. Alexey L. Arkov et al. EMBO J. 1998;17:1507-1514 ©1998 by European Molecular Biology Organization

5 Estimation of defects of mutant ribosomes in peptidyl ‐ tRNA hydrolysis. Alexey L. Arkov et al. EMBO J. 1998;17:1507-1514 ©1998 by European Molecular Biology Organization

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