1. Chapter 2. Innate immunity

2. • The response to an initial infection Figure 2.1
- Innate immunity
- Early induced response
- Adaptive immune response

4. • The first line of host defense - Pathogens Figure 2
• The first line of host defense - Pathogens Figure Site of infection and protective immunity Figure Pathogens can damage tissues in a variety of different ways Figure 2.4

12. - An infection and the response
Figure 2.5
Many barriers against infection
Figure 2.6
Microbicidal chemical proteins
ㆍlysozyme Figure 2.7
ㆍphospholipase A
ㆍa-defensins (cryptdins) Figure 2.8
ㆍb-defensins Figure 2.9
ㆍq-defensins
ㆍelastase
ㆍC-type lectin
ㆍCathelicidine

20. Specialized physical and chemical barriers of epithelia
Figure 2.10

25. • The complement system and innate immunity - Lectin pathway - Classical pathway Figure Alternative pathway Figure 2.12 • C3 and C3 convertase C3a → induce inflammation C3b → binds pathogen surfaces - There are various types of C3 convertase depending on the complement pathway C3
C3 convertase

30. - mannose binding lectin
• The lectin pathway
- mannose binding lectin
• binds to mannose and fucose residues of pathogens
• collectin family
• associated with MASP-1 and MASP-2
- MASP-1 : may cleave C3 (?)
- MASP-2 : homologous to C1s
⇒ cleave C4, C2
- Ficollins
ㆍhave fibringen-like domains
ㆍspecific for oligosaccharidies containing acetylated sugar
ㆍassociated with MASP-1 and MASP-2
Figure 2.14
Figure 2.15