1. Results-Changes in symptoms non cancer patients: Edmonton 0-without symptom; 10-worst symptom N Licensee application First interview Second interview pvalue MeanstdMeanstdMeanstd Pain1068.71.46.82.55.82.6p<0.0001 Fatigue 1047.52.35.43.34.53.1p<0.0001 Nausea 1004.73.52.37.10.82.1p<0.0001 Depression 1015.63.52.63.122.8p<0.0001 Anxiety 1025.03.52.43.11.92.8p<0.0001 Sleepiness 1005.83.23.83.62.52.9p<0.0001 Appetite 1046.12.93.63.13.22.5p<0.0001 General feeling 997.62.74.82.94.32.5p<0.0001 Shortness of breath 912.93.71.32.40.92.1p<0.0001

2. Results-Changes in symptoms non cancer patients: BPI pain 0-without symptom; 10-worst symptom N Licensee application First interview Second interview pvalue MeanstdMeanstdMeanstd Worst pain in last 24 hours1078.81.57.52.56.92.7p<0.0001 Least pain in last 24 hours1007.22.13.92.73.72.7p<0.0001 Average pain in last 24 hours977.91.66.22.55.52.5p<0.0001 Pain now1067.91.852.94.82.9p<0.0001 Pain relief from medications in last 24 hours (%) 10230.330.169.522.572.224.1p<0.0001

3. Results-Changes in symptoms non cancer patients: BPI daily activities 0-do not interfere; 10-completely interferes N Licensee application First interview Second interview pvalue MeanstdMeanstdMeanstd General activity1028.11.75.33.24.93.2p<0.0001 Mood1057.92.14.73.45.13.3p<0.0001 Walking ability1027.12.65.83.35.73.1p<0.0001 Noraml work1008.21.96.33.45.93.2p<0.0001 Relationship with other people 1017.12.33.83.63.93.7p<0.0001 Sleep1018.225.13.64.63.7p<0.0001 Enjoyment of life1058.51.85.43.35.33.5p<0.0001