1. S PIKE LATENCY AND JITTER OF NEURONAL MEMBRANE PATCHES WITH STOCHASTIC H ODGKIN –H UXLEY CHANNELS Mahmut Ozer, MuhammetUzuntarla, Matjaž Perc, Lyle J.Graham * Zonguldak Karaelmas University, Turkey * University of Maribor, Slovenia * Laboratory of Neurophysics and Physiology, France * Journal of Theoretical Biology, 2009 1 VC Lab, Dept. of Computer Science, NTHU, Taiwan

2. O VERVIEW Introduction Stochastic Resonance Neuron Na, K Model and Methods Simulation data Real data Conclusion Reference 2 VC Lab, Dept. of Computer Science, NTHU, Taiwan

3. I NTRODUCTION Stochastic Resonance 3 VC Lab, Dept. of Computer Science, NTHU, Taiwan http://www.umsl.edu/~neurodyn/assets/pdf/VisualSR.pdf

4. I NTRODUCTION Neuron 4 VC Lab, Dept. of Computer Science, NTHU, Taiwan http://www.nia.nih.gov/NR/rdonlyres/4E12F6CF-2436-47DB-8CC5-607E82B2B8E4/2372/neurons_big1.jpg http://people.eku.edu/ritchisong/301images/Neuron_action_potential.jpg

5. I NTRODUCTION Neuron 5 VC Lab, Dept. of Computer Science, NTHU, Taiwan http://www.nia.nih.gov/NR/rdonlyres/4E12F6CF-2436-47DB-8CC5-607E82B2B8E4/2372/neurons_big1.jpg http://faculty.washington.edu/chudler/ap.html

6. I NTRODUCTION Na, K 6 VC Lab, Dept. of Computer Science, NTHU, Taiwan http://people.eku.edu/ritchisong/301images/potassiumchannel_ionflow.jpg

7. M ODEL AND M ETHODS Hodgkin and Huxley model (H-H) Noise 7 VC Lab, Dept. of Computer Science, NTHU, Taiwan

8. M ODEL AND M ETHODS Mean Latency(ML) Standard Deviation of the Latencies 8 VC Lab, Dept. of Computer Science, NTHU, Taiwan

9. R ESULTS Dependence of latency and jitter on channel noise during spontaneous firing 9 VC Lab, Dept. of Computer Science, NTHU, Taiwan

10. R ESULTS Dependence of latency and jitter on channel noise and input frequency 10 VC Lab, Dept. of Computer Science, NTHU, Taiwan

11. R ESULTS Dependence of latency and jitter on the initial input phase 11 VC Lab, Dept. of Computer Science, NTHU, Taiwan

12. C ONCLUSION NDD(noise delayed decay) Low-pass filter in subthreshold regions Channels may enhance the range of input frequencies for effective detection of first spikes 12 VC Lab, Dept. of Computer Science, NTHU, Taiwan

13. R EFERENCE http://people.eku.edu/ritchisong/301notes2.htm Daqing Guo, Chunguang Li, Stochastic and coherence resonance in feed-forward-loop neuronal network motifs, Physical Review E 79, 2009 http://beaver.dlc.ncnu.edu.tw/projects/emag/show. aspx?dataId=f594b906-2b27-11d4-b17f- 0050bae32d5f 13 VC Lab, Dept. of Computer Science, NTHU, Taiwan