1. CADMOS Expt & P/L Support_POIWG#35 I 28-31/01/2014 I MSFC, Huntsville January 28-31, 2014 Alain MAILLET CADMOS Payloads & Experiments Support - Inc 39 & 40 POIWG#35

2. SUMMARY 2 CADMOS Expt & P/L Support_POIWG#35 I 28-31/01/2014 I MSFC, Huntsville  CADMOS Support during Increment 39-40  EPM COMING CHANGES WITH ARRIVAL OF PK-4:  Time Sequence Overview  Activities for Inc 39/40  Crew time estimation  MARES Battery R&R and Com part #1  EXPERIMENT STATUS – REVERSIBLE FIGURES  BACK-UP SLIDES :  ENERGY (see also DAMEC Presentation)  BP-REG (see also CSA Presentation)

3. SUMMARY 3 CADMOS Expt & P/L Support_POIWG#35 I 28-31/01/2014 I MSFC, Huntsville Ops LeadsExperiments (activity prime) Lucie CampagnoloENERGY, REVERSIBLE FIGURES, DOSIS-3D, GRIP, CRHYT Stéphanie HerrBP REG, ENERGY, MARES, REVERSIBLE FIGURES, SARCOLAB, CRHYT Anaïs Llodra-PerezUnder certification Alain MailletEPM, DOSIS-3D, ENERGY, MARES, CRHYT Maurice MarnatGRIP, REVERSIBLE FIGURES, BP REG, EPM Lourdes Oro Marot REVERSIBLE FIGURES, MARES, DOSIS-3D, ENERGY, SARCOLAB, PK-4, CRHYT Hélène RugetDOSIS-3D, ENERGY, MARES, SARCOLAB, BP REG, CRHYT Cécile ThevenotDOSIS-3D, ENERGY, EPM, PK-4, CRHYT Stéphanie Anaïs Hélène Cécile Maurice CADMOS OPS Team Lourdes Alain Lucie

4. 4 CADMOS Expt & P/L Support_POIWG#35 I 28-31/01/2014 I MSFC, Huntsville CADMOS SUPPORT DURING INCREMENTS 39-40 EPM  EPM reconfig. In prep of PK-4  EPM Maintenance:  EPM Laptop SW + CADMOS consoles SW Upgrades  EPM Video Unit C/O (readiness for PK-4, GRIP) MARES  MARES Battery replacement  MARES Commissioning Part 1 EXPERIMENTS  BP-Reg  ENERGY  DOSIS 3D  REVERSIBLE FIGURES  CIRCADIAN RHYTHMS w. Armband GROUND ONLY  CARTILAGE  EDOS (to be completed inc 40)

5. CADMOS Expt & P/L Support_POIWG#35 I 28-31/01/2014 I MSFC, Huntsville EPM RECONFIG FOR PK-4 Increment 39-40

6. 6 CADMOS Expt & P/L Support_POIWG#35 I 28-31/01/2014 I MSFC, Huntsville EPM in-orbit Preparation Activities Current Configuration EAC JSC CTC JSC EPM Current Configuration V1 Theory That's was the reality (Inc31)!

7. 7 CADMOS Expt & P/L Support_POIWG#35 I 28-31/01/2014 I MSFC, Huntsville EPM in-orbit Preparation Activities Current Configuration EAC JSC CTC JSC EPM Current Configuration V1 TheoryEven better (Inc36) !  EPM-CLEAN (30 min) Tasklist activity  Picture of EPM front  Adjustement of EPM- CLEAN activity

8. 8 CADMOS Expt & P/L Support_POIWG#35 I 28-31/01/2014 I MSFC, Huntsville EPM HW Overview (EPM – MEEMM et CDL)  ESA Multi-User Facility Rack  Physiology Rack  CADMOS FRC  Science Modules  Cardiolab (CNES-DLR) »Few biomed Instruments => Active component  MEEMM (ESA)  Stowage Modules  3 Containers (8 PU)  Facility Container (EPM-Laptop)  NASA Container (4 PU) »Handgrip Dynamometer »…

9. 9 CADMOS Expt & P/L Support_POIWG#35 I 28-31/01/2014 I MSFC, Huntsville EPM HW Overview (EPM – MEEMM et CDL)  ESA Multi-User Facility Rack  Physiology Rack  CADMOS FRC  Science Modules  Cardiolab (CNES-DLR) »Few biomed Instruments => Active component  MEEMM (ESA)  Stowage Modules  3 Containers (8 PU)  Facility Container (EPM-Laptop)  NASA Container (4 PU) »Handgrip Dynamometer »…

10. 10 CADMOS Expt & P/L Support_POIWG#35 I 28-31/01/2014 I MSFC, Huntsville EPM HW Overview (EPM – MEEMM et CDL)  ESA Multi-User Facility Rack  Physiology Rack  CADMOS FRC  Science Modules  Cardiolab (CNES-DLR) »Few biomed Instruments => Active component  MEEMM (ESA)  Stowage Modules  3 Containers (8 PU)  Facility Container (EPM-Laptop)  NASA Container (4 PU) »Handgrip Dynamometer »… EPM config tables update ! Impact on BP-Reg !

11. 11 CADMOS Expt & P/L Support_POIWG#35 I 28-31/01/2014 I MSFC, Huntsville EPM HW Overview (EPM – MEEMM et CDL)  ESA Multi-User Facility Rack  Physiology Rack  CADMOS FRC  Science Modules  Cardiolab (CNES-DLR)  MEEMM (ESA)  Stowage Modules  3 Containers (8 PU) reduced to 1  Facility Container (EPM-Laptop) - OK  NASA Container (4 PU) »Handgrip Dynamometer »… »It will move two times:  First to F1 (EPM v1.1-05/2014)  Second to C2 (EPM v2-11/2014)

12. 12 CADMOS Expt & P/L Support_POIWG#35 I 28-31/01/2014 I MSFC, Huntsville EPM in-orbit Preparation Activities Overview EAC JSC CTC JSC EPM Current Configuration V1 EPM Configuration V1.1EPM Configuration V2 with PK4

13. 13 CADMOS Expt & P/L Support_POIWG#35 I 28-31/01/2014 I MSFC, Huntsville EPM in-orbit Preparation Activities Inc 39/40 EAC JSC CTC JSC EPM Current Configuration V1 EPM Configuration V1.1  EPM-RECONFIG-V1.1 (120 min)

14. 14 CADMOS Expt & P/L Support_POIWG#35 I 28-31/01/2014 I MSFC, Huntsville EPM in-orbit Preparation Activities Overview

15. 15 CADMOS Expt & P/L Support_POIWG#35 I 28-31/01/2014 I MSFC, Huntsville Activities overview EPM Clean-up EPM rack reconf. V1.1 EPM Config table update (Gnd only) Main HardwareCADMOS: EPM Rack, EPM Laptop, EPM FCC SubjectsOne operator needed Implementation The following sequence should be implemented: EPM Clean-up EPM rack reconf. V1.1 EPM Config table update (Gnd only) Crew timeSee next table CADMOS Data All logs generated during EPM activities are forwarded to OHB for analysis Photo / Video Video is highly desired: crew shall set up the camera so the EPM rack is clearly visible. VCA adj is included in PODF EPM activities In preparation of PK4

16. 16 CADMOS Expt & P/L Support_POIWG#35 I 28-31/01/2014 I MSFC, Huntsville EPM Activities ESA utilisation Crew time IncrementActivityCrew timeNum. Crew Inc 37-38EPM FCC SW updateN/A Inc 39-40?EPM Video Unit C/O1h (TBC)1 Inc 39-40EPM Clean301 Inc 39-40EPM rack reconf. V1,12h1 Inc 39-40EPM Config table update (Gnd only)N/A Total Crew Time2h30 - 3h30 Total Crew Time Inc 39 – 40: 3h30 IncrementActivityCrew timeNum. Crew Inc 41-42CLSW Ghost Image update1h1 Inc 41-42Stow EPM rack items1 – 2h (TBD)1 Inc 41-42PK-4 FACILITY MECHANICAL INSTALLATION 6h2 Inc 41-42PK-4 EXTERNAL HARNESS INSTALLATION 2h1 Inc 41-42PK-4 EXCHANGE OF RDS20 min1 Crew Time Inc 41 – 42 : 11h20min

17. CADMOS Expt & P/L Support_POIWG#35 I 28-31/01/2014 I MSFC, Huntsville MARES BATTERY R&R MARES COM P. #1 Increment 40

18. 18 CADMOS Expt & P/L Support_POIWG#35 I 28-31/01/2014 I MSFC, Huntsville MARES is an ESA / NASA cooperation to perform Muscle research on board the ISS. MARES (Muscle Astrophy Research and Exercise System) Scientific Background V ibration I solation F rame MainBox Pantograph Chair

19. 19 CADMOS Expt & P/L Support_POIWG#35 I 28-31/01/2014 I MSFC, Huntsville MARES Operational background Launch on 2010 Commissioning part #1 attempts  Failure on the Battery Need of two new activities: Battery Replacement Commissioning part # 1 Battery

20. 20 CADMOS Expt & P/L Support_POIWG#35 I 28-31/01/2014 I MSFC, Huntsville → Two consecutive days to optimize the crew time MARES Inc 39-40 Battery Replacement New battery design (No loss of charge when OFF) Upload on ATV5 MARES rack needs to be partially deployed Com Part # 1 Only hardware testing (No subject on the chair) Two days activity MARES activation and commissioning + downlink of the logs for analysis

21. 21 CADMOS Expt & P/L Support_POIWG#35 I 28-31/01/2014 I MSFC, Huntsville MARES Battery Replacement and Commissioning Part 1 back to back Activities MARES Battery Replacement followed by MARES Commissioning Part 1 = functional test of MARES Main Hardware MARES, MARES Battery Spare, EPM Laptop A31p & Ext. HD, EPM Rack Crews (x2) The following crew scenarios are possible (Inc 40): - Gerst (Operator) + Swanson (Support); - Swanson (Operator) + Gerst (Support); - Swanson (Operator) + Wiseman (Support); - Gerst (Operator) + Wiseman (Support); Implementation 2 days activities MARES can be planned after ATV5 (MARES Battery spare upload on ATV5) Crew time See next pages Data Data stored on MARES and EPM Laptop Data downlink via EPM High Rate Photo / Video Video required for Day 1 and Day 2 (Camera adjustment include in the procedure)

22. 22 CADMOS Expt & P/L Support_POIWG#35 I 28-31/01/2014 I MSFC, Huntsville MARES DAY 1: Battery Replacement + deployment and Battery charge Partial deployment for Battery replacement Final deployment for Com Part 1 configuration

23. 23 CADMOS Expt & P/L Support_POIWG#35 I 28-31/01/2014 I MSFC, Huntsville MARES DAY 2: Commissioning Part 1 + Battery discharge + Stowage and Data downlink Expected data to be downlinked: Commissioning reports (  100 MB) Commissioning logs (  1 MB) Total crew time: DAY 1  230 mn + DAY 2  240 mn = 470 mn (07:50)

24. CADMOS Expt & P/L Support_POIWG#35 I 28-31/01/2014 I MSFC, Huntsville REVERSIBLE FIGURES Increment 39-40

25. 25 CADMOS Expt & P/L Support_POIWG#35 I 28-31/01/2014 I MSFC, Huntsville REVERSIBLE FIGURES Perceived reversals during visualization of perspective-reversible figures Science overview Investigate whether the perception of ambiguous figures is affected by microgravity. The experiment will compare the percept reversals during the visualization of perspective-reversible figures in astronauts before, during and after long-term duration exposure to microgravity. Free floating required Main Hardware ESA MultiPurpose Payload Laptop Visor, Trackball, dedicated Hard disk, PCMCIA Card Subjects Inc 39-40: K. Wakata, A Gerst (R) 4 subjects completed, 2 on-going / 6 subject required – Wakata should conclude the experiment !!! Implementation 6 sessions per subject (4 mandatory) Crew time 65 min per session + 10 min after last session for data downlink Combining subjects session = Gain crew time Data Data stored on PCMCIA card – downlink to ground via OCA Photo / Video Video desired to check free floating position

26. 26 CADMOS Expt & P/L Support_POIWG#35 I 28-31/01/2014 I MSFC, Huntsville REVERSIBLE FIGURES Perceived reversals during visualization of perspective-reversible figures Head mounted display (visor) Setup in Columbus starboard cone Hard Disk and Ultrabay Adapter Trackball

27. 27 CADMOS Expt & P/L Support_POIWG#35 I 28-31/01/2014 I MSFC, Huntsville ExperimentsPre-flightPost-flight ENERGY Between L-150 and L-30 DEXA scan b/w L-365d and L0 Body mass before launch Body mass between R+0 and R+7d DEXA scan between R+0d and R+1y REVERSIBLE FIGURES L-120 ±30d, L-90 ±30d, L-60 ±30dR+1 ±1d, R+4 ±2d, R+8 ±2d GRIP 3 session > L-180R+1, R+3±1d, R+12±2d, 2x >R+30 CARTILAGE 1 session on 2 days (blood x 2 days, urine x 2 days, MRI one of the 2 days) ideally in the 14 days pre-flight, no fixed date necessary (before the crew’s last travel to GCTC R+1(-0/+1): early blood and urine collection (fasting) on 1 day only, no MRI R+ 2 to 7 days: Complete session on 2 days R+ 4 to 6 weeks: Complete session EDOS L-60d, L-30d R+1d (BM), R+2d (XCT), R+15d (BM), R+90d(BM & XCT), R+180d (BM & XCT), R+360d ±2w Baseline Data Collection Overview EAC JSC GCTC JSC

28. 28 CADMOS Expt & P/L Support_POIWG#35 I 28-31/01/2014 I MSFC, Huntsville BACKUP SLIDES THANK YOU FOR YOUR ATTENTION

29. CADMOS Expt & P/L Support_POIWG#35 I 28-31/01/2014 I MSFC, Huntsville ENERGY Increment 39-40

30. 30 CADMOS Expt & P/L Support_POIWG#35 I 28-31/01/2014 I MSFC, Huntsville ENERGY Astronaut’s energy requirements for long-term space flights (support to DAMEC) Science overview Measure energy requirements before and during long-term space flight (>90 days), through doubly labeled water (DLW) intake to measure total energy expenditure (TEE) and body composition Main Hardware DAMEC: PFS (in HRF2) including MBS system, PFS Face Mask Kit, Energy kit CADMOS: EPM & EPM Laptop, Energy Armband Kit, Energy Food Kit, Energy Urine Collection Kit, Energy Sample Kit, Energy Armband Consumable Kit, Energy UltraBay Wallet, Water Sampling Kit, Energy Water Kit, Urine Containment Bag Kit Coordinated ops with NASA for PFS, Water Sampling done from US P/L PWD only Subjects Inc 39-40:A. gerst, G. Wiseman Number of inflight subjects already performed: 6 out of 9 Implementation 1 session of 11 days, from L+90 days (18/03/2013) to R-3 weeks (23/04/2013) Crew time A subject : 5.83hrs for PFS + 4.83hrs for ENERGY stand-alone. Data Samples downloaded at ambient temperature, data downlinked via EPM Photo / Video N/A Laptop transition T61p is used (A31p will remain as b/u solution: to be stowed in EPM facility container)

31. 31 CADMOS Expt & P/L Support_POIWG#35 I 28-31/01/2014 I MSFC, Huntsville ENERGY Inc 39-40 sessions A. Gerst and G. Wiseman ENERGY science window From L+90 days (26/08/2014) to R-3 weeks (27/10/2014) (as per last ESR version, window can be extended to R-2 weeks  03/11/2014) ENERGY Consumables New one will be uploaded on ATV5 ENERGY Food kits status Upload on ATV5 (today docking on 17/06/2014), so if delay of ATV5:  session to be moved to the right (depending on ATV5 launch delay)  or solutions will have to be found to replace food: several options are workable (use of food containers from Pettit and Acaba + ISS food), already discussed off line but to be studied more in details Addition of a control subject: Either Gerst or Wiseman Day 1: 1 Urine sampling before lunch but after DLW intake from subject Day 2-4-6-8-10: Urine sampling +/- 1 hours from subject No other scientific contraints => Changes in ATV5 upload with additional Stowage tube to collect Control urine samples

32. 32 CADMOS Expt & P/L Support_POIWG#35 I 28-31/01/2014 I MSFC, Huntsville ENERGY Astronaut’s energy requirements for long-term space flights (support to DAMEC) Armband Energy Sample Kit Energy Water Kit Energy Armband Consumable Kit Energy Water Dispenser ENERGY Food Kit Energy Urine Collection Kit

33. 33 CADMOS Expt & P/L Support_POIWG#35 I 28-31/01/2014 I MSFC, Huntsville BP REG A Simple In-flight Method to Test the Risk of Fainting on Return to Earth After Long-Duration Space Flights Science overview CSA experiment The objective of this experiment is to test the efficacy of an in-flight manipulation of arterial blood pressure (BP) as an indicator of post-flight response to a brief stand test. Space flight negatively impacts the regulation of BP on return to upright posture on earth. A Leg Cuff test will challenge BP regulation by inducing a brief drop in BP following the release of a short occlusion of blood flow to the legs. The change in BP from pre- to in-flight will be used to predict those astronauts who will experience the greatest drop in BP in the post-flight stand test. Main Hardware CADMOS: Cardiolab (CDL), part of the European Physiology Modules (EPM), controlling the Leg- Arm Cuff System (LACS) DAMEC: Pulmonary Function System (PFS), part of the Human Research Facility 2 (HRF-2) NASA: Continuous Blood Pressure Device (CBPD), getting power from HRF-2 Subjects Inc 39-40: (8 subjects required – 4 remaining) Implementation Measurement A: Continuous BP during Leg Cuff (EPM+CDL+LACS+ NASA CBPD) Measurement B: Continuous BP during Cardiac Output while rebreathing: (HRF- 2+PFS+PAM+PFM+GDS +CBPD) Crew time Under CSA allocation CADMOS Data LACS data stored on CARDIOLAB – downlink to ground via EPM (Medium Rate) Photo / Video Video (Leg cuff protocol, PFM/PAM calibration, rebreathing), R4 restricted (NASA TV Restricted) If countermeasures are used: Measurements A+B, at R-30 ± 7d, and then measurement A at R-7 to R-0) If no countermeasures are used: Measurements A+B, at R-30 ±7d

34. 34 CADMOS Expt & P/L Support_POIWG#35 I 28-31/01/2014 I MSFC, Huntsville BPBlood PressureHRFHuman Research Facility CDLCardiolabLACSLeg/Arm Cuffs System ECGElectrocardiogramMEEMMMulti ElectroEncephalogramme Mapping Module EEGElectroencephalogramMELFIMinus Eighty Degree Laboratory Freezer for ISS EOGElectrooculogramPCBAPortable Clinical Blood Analyzer EPMEuropean Physiology Modules Facility RCRefrigerated Centrifuge HDHard DiskSWSoftware ACRONYMS