1. Unit 4 Seminar Cellular immunity Immunology Dr. Furr

2. A quick review…… How is cellular immunity (T cell) different than humoral (B cell) immunity? B cells- produce antibodies Killer T cells (CTLs)- release chemicals to destroy infected cells, cancer cells

3. T cell activation CTLs and T helper cells are activated in a similar way: 2 signals needed to activate naïve cells: 1.Antigen recognition on MHC II of antigen presenting cell 2.Co-stimulatory signal from same cell

4. Differentiate between: killer T cells, Th 1 cells, Th 2 cells, Th 17 cells, and T 0 cells. Killer T cells- -CD8+ -Recognize antigen on MHC I Th1 cells- -Bacterial or viral infection in the tissues -Release cytokines to charge macrophages and NK Th2 cells- -Parasites and bacterial infections

5. Differentiate between: killer T cells, Th 1 cells, Th 2 cells, Th 17 cells, and T 0 cells. Th 17 cells- -fungal infections, some bacteria -Triggers neutrophil activation T 0 cells- -uncommitted until they reach the site of infection -Differentiate into Th 1 cells, Th 2 cells, or Th 17 cells * Why are these cells important??

6. Consider the following case studies and interpret the results. What kind of infection does the patient most likely have? How can you tell?

7. Case A- Elevated killer T cell levels, elevated Th 1 cell levels

8. Viral or bacterial infection in the tissues What does the high CTL count mean??

9. Case B- Elevated B cell levels, elevated Th 2 cell levels

10. -parasites or intestinal bacterial infection - Th2 cells secrete cytokines that charge NK and MO cells

11. Case C- Elevated Th 17 cell levels, elevated macrophage and neutrophil levels

12. Most likely a fungal infection Release of IL-17 triggers MO and neutrophil activation

13. Unit 4 assignment Researching the Immune System In this research writing assignment you will be composing an essay in which you provide a 700- 1,000 word response to the specific questions below. You should include a well developed introduction and conclusion. Be sure to answer all parts of each question in full and complete sentences and support your answers with research. You should consult at least three references including your textbook.

14. Assignment questions: Compare and contrast the major roles of the innate immune system and the acquired immune system. How do the innate immune system and the acquired immune system work together to fight infectious agents? Basic Writing Expectations Your report should be at least 700-1,000 words, not counting the title or reference pp. Include a separate title page and reference page. Double space, font size 10 to 12 pt. Include a highly developed viewpoint/thesis, purpose and exceptional content. Demonstrate superior organization: use logic. Make certain that your paper is free of grammatical and spelling errors. Avoid plagiarism. Use APA style for all in-text citations and references. Always include an introduction and conclusion.