1. Web: www.immunology.unideb.huwww.immunology.unideb.hu Downloads Login: student Password: download Materials for the lectures and seminars can be downloaded: List of books: Peter Parham: The Immune system Abbas: Basic Immunology Raif Geha, Luigi Notarangelo: Case Studies in immunology

2. Requirements for Medicine Students –Changing of the seminar group – week 1-3 with permission from the Department –Absences from the seminars: More than two absences from the seminars – Department will refuse to sign the student’s Lecture book Possibility for make up (on the same week of the seminar, should be communicated to both seminar teachers) –Syllabus of the practices: (by the end of week 6 will be on the website) –SCTs: week 5, 11, 15 (Thursdays 06:30 pm): 8 th of October 2015. 06:30 pm – 19 th of November 2015. 06:30 pm – 17 th of December 2015. 06:30 pm - –Tresholds: 1 st SCT above 70% 2 nd and 3 rd SCT above 50% 170,1 – 205: pass (2) 205,1 – 240: satisfactory (3) 240,1 – 270: good (4) 270,1 – 300: excellent (5)

3. Organization of the lymphoid organs and tissues

4. Primary lymphoid organs : - Bone marrow - Thymus Secondary lymphoid organs: - Spleen - Lymphatic vessels - Lymph nodes - Adenoids and tonsils - MALT (Mucosal Associated Lymphoid Tissue) GALT (Gut Associated Lymphoid Tissue) BALT (Bronchus Associated Lymphoid Tissue) SALT (Skin Associated Lymphoid Tissue) NALT (Nasal Associated Lymphoid Tissue) LYMPHOID ORGANS

5. CELL TYPES OF THE BONE MARROW Dendritic cell B-cell precursors Stem cellsStromal cells BONE Central sinus Unspecialized stem cells with unlimited proliferating capacity Osteoblasts Osteoclasts ProgenitorsPrecursors Blood circulation

6. DC macrophage MYELOID PRECURSOR BONE MARROW HSC HEMATOPOIETIC STEM CELL mast DC monocyte neutrophil mast neutrophil TISSUES BLOOD B-cellT-cell NK-cell THYMUS B-cell LYMPHOID PRECURSOR LYMPHOID TISSUES BLOOD

7. Blood circulation Macrophage Hassall’s corpuscle Dendritic cell Thymocytes Epithelial cells Capsule Septum Mature naive T- lymphocytes STRUCTURE OF THE THYMUS Thymocytes from the bone marrow arrive at the thymus and mature into T cells

8. Lymphatic nodes

9. Lymphatic vessels

10. Lymph node

11. . The spleen filters the blood and serves as a secondary lymphoid organ NO LYMPHOID CIRCULATION

12. The small intestine contains lymphoid nodules; the Peyer’s patches and isolated lymphoid follicles. Pathogens are delivered across the mucosa to APCs by specialized mucosal epithelial cells are called the M cells (microfold cells). The Lamina propria contains lymphatic tissue underlying the gastrointestinal tract connective tissue GALT

13. Cellular components of the cutaneous immune system