1. Lecture 29: Calculate GFR Infants – Normal: 2.0 mg/L (0.2 mg/dL) – Kidney Disease: >20.0 mg/L (2 mg/dL) Adults Males: 6-12 mg/L (0.6-1.2 mg/dL) Females: 5-11 mg/L (0.5-1.1 mg/dL) One Kidney: 8-19 mg/L (0.8-1.9 mg/dL) Weight Lifter: > 12 mg/L (1.2 mg/dL) Disease >100 mg/L (10 mg/dL) 1

2. Lecture 29: Calculate GFR k = 0.33 in preemie infants (h = 0.5 m or 50 cm) k= 0.45 in infants to 1 year (h = 0.5 m or 50 cm) k = 0.55 to 13 years of age (h = 1 m or 100 cm) k = 0.55 female >13 years (h=1.5 m or 150 cm) k=0.70 males >13 years (h= 2 m or 200 cm) Example: Normal Infant k=0.45 h=50 cm [Creatine]p=0.2 mg/dL 2

3. Lecture 29: Calculate GFR-Things to Memorize Age Groupheight (cm/m)[Creatine] plasma [Creatine] plasma (Disease) Infants50 cm/0.5 m0.2 mg/dL>2 mg/dL Young Children (1- 6) 100 cm/ 1.0 m1.0 mg/dL>10 mg/dL Children (6-13)150 cm / 1.5 m1.0 mg/dL> 10 mg/dL Adults (>13)200 cm/ 2 m1.0 mg/dL> 10 mg/dL Example: An infant has a [creatine]plasma of 5.0 mg/dL. Does the infant have problems with their kidneys? 3

4. Lecture 30: Calculate BMI 4

5. Lecture 30: Calculate Individual Maintenance Remember: Older people almost always get a lower dose. 5

6. PK of Progeria Healthy Nucleus Progeria Nucleus 6

7. SPECIAL POPULATIONS: GENDER Lecture #31 7

8. Lean Body Mass 4% higher lean body weight Example: Man and Woman 70 kg and 2 m in height. 8

9. Weight 9

10. Differences 10

11. Body Composition 11

12. Disease 12

13. Disease male female 13

14. Drug Trials Thalidomide 14

15. Long QT Syndrome Rare inherited Torsades de pointes Higher risk with females 15

16. QT Hypothesis 16

17. Multiple Sclerosis 17

18. Factoid MS incidence Hookworm incidence 18

19. Factoid Am I a drug? 19

20. Gender-based Recommendations 20

21. ADR 21

22. ADME 22 Age Dependent

23. ME part 23

24. A 24

25. M [Drug] Male Female Circles=Nicardipine Triangles=Nifedipine Normalized mRNA Expression Level (Konno, 2004 Toxicology and Applied Pharmacology) 25

26. M 26

27. M: Phase II 27

28. M: Regulation 28

29. M: Regulation 29

30. M: Pregnancy (Choi, 2011 Biochemical Pharmacology) 30

31. M 31

32. E: Renal 32

33. PD 33

34. PD: Mother  Infant 34