1. Tissues PART 1

2. Tissues  Cells work together in functionally related groups called tissues  Tissue A group of closely associated cells that perform related functions and are similar in structure

3. Four Basic Tissue Types and Basic Functions  Epithelial tissue – covering (Chapters 4 and 5)  Connective tissue – support (Chapters 4, 5, 6, and 9)  Muscle tissue – movement (Chapters 10 and 11)  Nervous tissue – control (Chapters 12 – 16 and 25)

4. Epithelial Tissue  Covers a body surface or lines a body cavity  Forms parts of most glands-secretes hormones  Functions of epithelium Protection Absorption, secretion, and ion transport Filtration Forms slippery surfaces

5. Special Characteristics of Epithelia  Cellularity Cells separated by minimal extra cellular material  Specialized contacts Cells joined by special junctions  Polarity Cell regions of the apical surface differ from the basal surface

6. Special Characteristics of Epithelia  Support by connective tissue  Avascular but innervated Epithelia receive nutrients from underlying connective tissue  Regeneration Lost cells are quickly replaced by cell division

7. Special Characteristics of Epithelia Figure 4.1

8. Classifications of Epithelia  First name of tissue indicates number of cell layers Simple – one layer of cells Stratified – more than one layer of cells

9. Classifications of Epithelia  Last name of tissue describes shape of cells Squamous – cells are wider than tall (plate-like) Cuboidal – cells are as wide as tall, like cubes Columnar – cells are taller than they are wide, like columns

10. Classifications of Epithelia Figure 4.2

11. Simple Squamous Epithelium  Description – single layer – flat cells with disc-shaped nuclei  Specialized types Endothelium (inner covering) – slick lining of hollow organs Mesothelium (middle covering)  Lines peritoneal, pleural, pericardial cavities  Covers visceral organs of those cavities

12. Simple Squamous Epithelium  Function Passage of materials by passive diffusion and filtration Secretes lubricating substances in serosae  Location Renal corpuscles Alveoli of lungs Lining of heart, blood and lymphatic vessels Lining of ventral body cavity (serosae)

13. Simple Squamous Epithelium Figure 4.3a

14. Simple Cuboidal Epithelium  Description Single layer of cubelike cells with large, spherical central nuclei  Function Secretion and absorption  Location Kidney tubules, secretory portions of small glands, ovary surface

15. Simple Cuboidal Epithelium Figure 4.3b

16. Simple Columnar Epithelium  Description – single layer of column- shaped (rectangular) cells with oval nuclei Some bear cilia at their apical surface May contain goblet cells  Function Absorption; secretion of mucus, enzymes, and other substances Ciliated type propels mucus or reproductive cells by ciliary action

17. Simple Columnar Epithelium  Location Nonciliated form  Lines digestive tract, gallbladder, ducts of some glands Ciliated form  Lines small bronchi, uterine tubes, and uterus

18. Simple Columnar Epithelium Figure 4.3c

19. Pseudostratified Columnar Epithelium  Description All cells originate at basement membrane Only tall cells reach the apical surface May contain goblet cells and bear cilia Nuclei lie at varying heights within cells  Gives false impression of stratification

20. Pseudostratified Columnar Epithelium  Function – secretion of mucus; propulsion of mucus by cilia  Locations Nonciliated type  Ducts of male reproductive tubes  Ducts of large glands Ciliated variety  Lines trachea and most of upper respiratory tract

21. Pseudostratified Ciliated Columnar Epithelium Figure 4.3d

22. Stratified Epithelia  Properties Contain two or more layers of cells Regenerate from below (basal layer) Major role is protection Named according to shape of cells at apical layer

23. Stratified Squamous Epithelium  Description Many layers of cells – squamous in shape Deeper layers of cells appear cuboidal or columnar Thickest epithelial tissue  Adapted for protection from abrasion

24. Stratified Squamous Epithelium  Two types Keratinized and nonkeratinized  Keratinized Location – epidermis Contains the protective protein keratin Waterproof Surface cells are dead and full of keratin

25. Stratified Squamous Epithelial Tissue Nonkeratinized  Forms moist lining of body openings

26. Stratified Squamous Epithelium  Function – Protects underlying tissues in areas subject to abrasion  Location Keratinized – forms epidermis Nonkeratinized – forms lining of mucous membranes  Esophagus  Mouth  Anus  Vagina  Urethra

27. Stratified Squamous Epithelium Figure 4.3e

28. Stratified Cuboidal Epithelium  Description – generally two layers of cube-shaped cells  Function – protection  Location Forms ducts of  Mammary glands  Salivary glands  Largest sweat glands

29. Stratified Cuboidal Epithelium Figure 4.3f

30. Stratified Columnar Epithelium  Description – several layers; basal cells usually cuboidal; superficial cells elongated  Function – protection and secretion  Location Rare tissue type Found in male urethra and large ducts of some glands

31. Stratified Columnar Epithelium Figure 4.3g

32. Transitional Epithelium  Description Basal cells usually cuboidal or columnar Superficial cells dome-shaped or squamous  Function – stretches and permits distension of urinary bladder  Location Lines  Ureters, urinary bladder  Proximal urethra

33. Transitional Epithelium Figure 4.3h

34. Exocrine Glands  Ducts carry products of exocrine glands to epithelial surface  Include the following diverse glands Mucus-secreting glands Sweat and oil glands Salivary glands Liver and pancreas

35. Unicellular Exocrine Glands (The Goblet Cell)  Goblet cells produce mucin Mucin + water  mucus Protects and lubricates many internal body surfaces Goblet cells are a unicellular exocrine gland

36. Goblet Cells Figure 4.5

37. Multicellular Exocrine Glands  Have two basic parts Epithelium-walled duct Secretory unit

38. Multicellular Exocrine Glands  Classified by structure of duct Simple Compound  Categorized by secretory unit Tubular Alveolar Tubuloalveolar

39. Types of Multicellular Exocrine Glands Figure 4.6

40. Endocrine Glands  Endocrine glands are ductless glands Secrete substances directly into bloodstream Produce molecules called hormones

41. Lateral Surface Features – Cell Junctions  Factors holding epithelial cells together Adhesion proteins link plasma membranes of adjacent cells Contours of adjacent cell membranes  (Like puzzle pieces) Special cell junctions

42. Lateral Surface Features – Cell Junctions  Tight junctions (zona occludens) – close off intercellular space Found at apical region of most epithelial tissues types Some proteins in plasma membrane of adjacent cells are fused Prevent certain molecules from passing between cells of epithelial tissue

43. Tight Junction Figure 4.7a

44. Lateral Surface Features – Cell Junctions  Adherens junctions (zonula adherens) – anchoring junction Transmembrane linker proteins attach to actin microfilaments of the cytoskeleton and bind adjacent cells  With tight junctions, form the tight junctional complex around apical lateral borders of epithelial tissues

45. Lateral Surface Features – Cell Junctions  Desmosomes – two disclike plaques connected across intercellular space Plaques of adjoining cells are joined by proteins called cadherins  Regulate cell shape/structure by cell-cell interactions  Class of calcium-dependent adhesion molecules

46. Lateral Surface Features – Cell Junctions Proteins interdigitate into extracellular space Intermediate filaments insert into plaques from cytoplasmic side Also found in the heart

47. Desmosome Figure 4.7b

48. Lateral Surface Features – Cell Junctions  Gap junctions – passageway between two adjacent cells Let small molecules move directly between neighboring cells Cells are connected by hollow cylinders of protein Function in intercellular communication

49. Gap Junction Figure 4.7c

50. Basal Feature: The Basal Lamina  Noncellular supporting sheet between the ET and the CT deep to it  Consists of proteins secreted by ET cells

51. Basal Feature: The Basal Lamina  Functions Acts as a selective filter, determining which molecules from capillaries enter the epithelium Acts as scaffolding along which regenerating ET cells can migrate  Basal lamina and reticular layers of the underlying CT deep to it form the basement membrane

52. Epithelial Surface Features  Apical surface features Microvilli – fingerlike extensions of plasma membrane  Abundant in ET of small intestine and kidney  Maximize surface area across which small molecules enter or leave  Act as stiff knobs that resist abrasion

53. Epithelial Surface Features  Apical surface features Cilia – whiplike, highly motile extensions of apical surface membranes  Contains a core of nine pairs of microtubules encircling one middle pair Axoneme – a set of microtubules Each pair of microtubules – arranged in a doublet  Microtubules in cilia – arranged similarly to cytoplasmic organelles called centrioles  Movement of cilia – in coordinated waves

54. A Cilium Figure 4.8

55. Classes of Connective Tissue  Most diverse and abundant tissue  Main classes Connective tissue proper Cartilage Bone tissue Blood  Cells separated by large amount of extracellular matrix  Common embryonic origin – mesenchyme  Extracellular matrix is composed of ground substance

56. Connective Tissue Proper  Has two subclasses Loose connective tissue  Areolar, adipose, and reticular Dense connective tissue  Dense irregular, dense regular, and elastic

57. Classes of Connective Tissue Figure 4.9

58. Areolar Connective Tissue – A Model Connective Tissue  Areolar connective tissue Underlies epithelial tissue Surrounds small nerves and blood vessels Has structures and functions shared by other CT Borders all other tissues in the body Is a “model” connective tissue – why?

59. Major Functions of Connective Tissue  Structures within areolar CT and function Support and binding of other tissues Holding body fluids (interstitial fluid  lymph) Defending body against infection Storing nutrients as fat

60. Areolar Connective Tissue  Fibers provide support Three types of protein fibers in extracellular matrix  Collagen fibers  Reticular fibers  Elastic fibers  Fibroblasts produce these fibers

61. Areolar Connective Tissue  Description Gel-like matrix with all three fiber types Cells of areolar CT  Fibroblasts, macrophages, mast cells, and white blood cells  Function Wraps and cushions organs Holds and conveys tissue fluid Important role in inflammation

62. Areolar Connective Tissue  Locations Widely distributed under epithelia Packages organs Surrounds capillaries

63. Areolar Connective Tissue Figure 4.12b

64. Areolar Connective Tissue  Tissue fluid (interstitial fluid) Watery fluid occupying extracellular matrix Tissue fluid derives from blood  Ground substance Viscous, spongy part of extracellular matrix Consists of sugar and protein molecules Made and secreted by fibroblasts

65. Areolar Connective Tissue  Main battlefield in fight against infection  Defenders gather at infection sites Macrophages Plasma cells Mast cells White blood cells  Neutrophils, lymphocytes, and eosinophils

66. Adipose Tissue  Description Closely packed adipocytes Have nucleus pushed to one side by fat droplet

67. Adipose Tissue  Function Provides reserve food fuel Insulates against heat loss Supports and protects organs  Location Under skin Around kidneys Behind eyeballs, within abdomen and in breasts

68. Adipose Tissue Figure 4.12c

69. Reticular Connective Tissue  Description – network of reticular fibers in loose ground substance  Function – form a soft, internal skeleton (stroma) – supports other cell types  Location – lymphoid organs Lymph nodes, bone marrow, and spleen

70. Reticular Connective Tissue Figure 4.12d

71. Dense Connective Tissue  Dense irregular connective tissue  Dense regular connective tissue  Elastic connective tissue

72. Dense Irregular Connective Tissue  Description Primarily irregularly arranged collagen fibers Some elastic fibers and fibroblasts

73. Dense Irregular Connective Tissue  Function Withstands tension Provides structural strength  Location Dermis of skin Submucosa of digestive tract Fibrous capsules of joints and organs

74. Dense Irregular Connective Tissue Figure 4.12e

75. Dense Regular Connective Tissue  Description Primarily parallel collagen fibers Fibroblasts and some elastic fibers Poorly vascularized

76. Dense Regular Connective Tissue  Function Attaches muscle to bone Attaches bone to bone Withstands great stress in one direction  Location Tendons and ligaments Aponeuroses Fascia around muscles

77. Dense Regular Connective Tissue Figure 4.12f

78. Elastic Connective Tissue  Description Elastic fibers predominate  Function – allows recoil after stretching  Location Within walls of arteries, in certain ligaments, and surrounding bronchial tubes

79. Elastic Connective Tissue Figure 4.12g

80. Other Connective Tissues  Cartilage  Bone  Blood

81. Cartilage  Firm, flexible tissue  Contains no blood vessels or nerves  Matrix contains up to 80% water  Cell type – chondrocyte

82. Types of Cartilage  Hyaline cartilage  Elastic cartilage  Fibrocartilage

83. Hyaline Cartilage  Description Imperceptible collagen fibers (hyaline = glassy) Chodroblasts produce matrix Chondrocytes lie in lacunae

84. Hyaline Cartilage  Function Supports and reinforces Resilient cushion Resists repetitive stress

85. Hyaline Cartilage  Location Fetal skeleton Ends of long bones Costal cartilage of ribs Cartilages of nose, trachea, and larynx

86. Hyaline Cartilage Figure 4.12h

87. Elastic Cartilage  Description Similar to hyaline cartilage More elastic fibers in matrix

88. Elastic Cartilage  Function Maintains shape of structure Allows great flexibility  Location Supports external ear Epiglottis

89. Elastic Cartilage Figure 4.12i

90. Fibrocartilage  Description Matrix similar but less firm than hyaline cartilage Thick collagen fibers predominate  Function Tensile strength and ability to absorb compressive shock

91. Fibrocartilage  Location Intervertebral discs Pubic symphysis Discs of knee joint

92. Fibrocartilage Figure 4.12j

93. Bone Tissue  Description Calcified matrix containing many collagen fibers Osteoblasts – secrete collagen fibers and matrix Osteocytes – mature bone cells in lacunae Well vascularized

94. Bone Tissue  Function Supports and protects organs Provides levers and attachment site for muscles Stores calcium and other minerals Stores fat Marrow is site for blood cell formation  Location Bones

95. Bone Tissue Figure 4.12k

96. Blood Tissue  An atypical connective tissue  Develops from mesenchyme  Consists of cells surrounded by nonliving matrix

97. Blood Tissue  Description Red and white blood cells in a fluid matrix  Function Transport of respiratory gases, nutrients, and wastes  Location Within blood vessels

98. Blood Tissue Figure 4.12l

99. Covering and Lining Membranes  Combine epithelial tissues and connective tissues  Cover broad areas within body  Consist of epithelial sheet plus underlying connective tissue

100. Three Types of Membranes  Cutaneous membrane – skin  Mucous membrane Lines hollow organs that open to surface of body An epithelial sheet underlain with layer of lamina propria

101. Three Types of Membranes  Serous membrane – slippery membranes Simple squamous epithelium lying on areolar connective tissue Line closed cavities  Pleural, peritoneal, and pericardial cavities

102. Covering and Lining Membranes Figure 4.13a, b

103. Covering and Lining Membranes Figure 4.13c

104. Muscle Tissue  Skeletal muscle tissue  Cardiac muscle tissue  Smooth muscle tissue

105. Skeletal Muscle Tissue  Description Long, cylindrical cells Multinucleate Obvious striations

106. Skeletal Muscle Tissue  Function Voluntary movement Manipulation of environment Facial expression  Location Skeletal muscles attached to bones (occasionally to skin)

107. Skeletal Muscle Tissue Figure 4.14a

108. Cardiac Muscle Tissue  Description Branching cells, striated Generally uninucleate Cells interdigitate at intercalated discs

109. Cardiac Muscle Tissue  Function Contracts to propel blood into circulatory system  Location Occurs in walls of heart

110. Cardiac Muscle Tissue Figure 4.14b

111. Smooth Muscle Tissue  Description Spindle-shaped cells with central nuclei Arranged closely to form sheets No striations

112. Smooth Muscle Tissue  Function Propels substances along internal passageways Involuntary control  Location Mostly walls of hollow organs

113. Smooth Muscle Tissue Figure 4.14c

114. Nervous Tissue  Description Main components are brain, spinal cord, and nerves Contains two types of cells  Neurons – excitatory cells  Supporting cells (neuroglial cells)

115. Nervous Tissue  Function Transmit electrical signals from sensory receptors to effectors  Location Brain, spinal cord, and nerves

116. Nervous Tissue Figure 4.15

117. Tissue Response to Injury  Inflammatory response Nonspecific, local response Limits damage to injury site  Immune response Takes longer to develop and very specific Destroys particular microorganisms at site of infection

118. Inflammation  Acute inflammation Heat Redness Swelling Pain Chemicals signal nearby blood vessels to dilate  Histamine increases permeability of capillaries

119. Inflammation  Edema – accumulation of fluid Helps dilute toxins secreted by bacteria Brings oxygen and nutrients from blood Brings antibodies from blood to fight infection

120. Repair  Regeneration Replacement of destroyed tissue with same type of tissue  Fibrosis Proliferation of scar tissue  Organization Clot is replaced by granulation tissue

121. Capacity for Regenation Good – excellent:  ET, bone CT, areolar CT, dense irregular CT, and blood forming CT Moderate:  Smooth muscle, dense regular CT

122. Capacity for Regenation Weak:  Skeletal MT, cartilage None or almost none:  Cardiac MT, Nervous Tissue

123. Tissue Repair of a Skin Wound Figure 4.16a

124. Tissue Repair of a Skin Wound Figure 4.16b

125. Tissue Repair of a Skin Wound Figure 4.16c

126. The Tissues Throughout Life  At the end of second month of development Primary tissue types have appeared Major organs are in place  Adulthood Only a few tissues regenerate Many tissues still retain populations of stem cells

127. The Tissues Throughout Life  With increasing age Epithelia thin Collagen decreases Bones, muscles, and nervous tissue begin to atrophy Poor nutrition and poor circulation – poor health of tissues