Presentation is loading. Please wait.

Presentation is loading. Please wait.

The C. elegans Germline Stem Cell Niche Hall et al. 1999.

Published byEdith Edwards Modified over 8 years ago

Similar presentations

Presentation on theme: "The C. elegans Germline Stem Cell Niche Hall et al. 1999."— Presentation transcript:

1

2 The C. elegans Germline Stem Cell Niche Hall et al. 1999

3 oocyte sperm mitotic region meiotic region vulva embryo oocyte sperm mitotic region meiotic region vulva embryo spermatheca distal tip cell sheath pair #1 vulva uterus sheath pair #2 sheath pair #3 sheath pair #4 sheath pair #5

4

5 The Notch Signaling Pathway Delta/Serate/LAG-2 Family Ligands (DSL) Notch Receptors Presenilin cleaves the Notch intracellular domain upon ligand binding. The intracellular domain translocates to the nucleus where it interacts with TFs (CSL Family).

6

7 The Germline Proliferation Defective (Glp) Phenotype WT Germ Line glp-1 Mutant (nonfunctional) Stem cells are lost to differentiation as sperm. Austin and Kimble,1987

8 The Tumorous (Tum) Phenotype Stem cells accumulate at the expense of differentiation. glp-1 Mutant (hyperactive) Berry et al. 1997 WT Germ Line

9

10

11

12

13

14

15

16

17

18

19

Download ppt "The C. elegans Germline Stem Cell Niche Hall et al. 1999."

Similar presentations

Lecture 10 Types of lineage mutants Lateral inhibition in C. elegans Induction in C. elegans.

Lecture 10 Types of lineage mutants Lateral inhibition in C. elegans Induction in C. elegans.
Gametogenesis Once upon a time….. The Germ Plasm Embryos must establish the germ cells as cells which never differentiate until gametogenesis occurs Germ.

Gametogenesis Once upon a time….. The Germ Plasm Embryos must establish the germ cells as cells which never differentiate until gametogenesis occurs Germ.
The Notch-  -Secretase Pathway. Notch activation involves the proteolytic cleavage of the Notch ligand/receptor complex by  -secretase to release the.

The Notch-  -Secretase Pathway. Notch activation involves the proteolytic cleavage of the Notch ligand/receptor complex by  -secretase to release the.
Notch receptor activation and function. Lz Notch signaling completely changes the way that cells respond to other signaling pathways Flores et al., Cell.

Notch receptor activation and function. Lz Notch signaling completely changes the way that cells respond to other signaling pathways Flores et al., Cell.
Next lecture: Induction/Signaling Requirements of inducer and responder cells Cascades of inductive events are involved in forming organs Examples of the.

Next lecture: Induction/Signaling Requirements of inducer and responder cells Cascades of inductive events are involved in forming organs Examples of the.
Aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation. Developmental Cell.

Aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation. Developmental Cell.
E2A and acute lymphoblastic leukemias (ALL). A closer look at the E2A gene... Other names: TCF3, ITF1, and Factors E12/E47 Located on chromosome 19 Encodes.

E2A and acute lymphoblastic leukemias (ALL). A closer look at the E2A gene... Other names: TCF3, ITF1, and Factors E12/E47 Located on chromosome 19 Encodes.
Notch1 Transmembrane Receptor Oncogene. What is Notch1?  Transmembrane protein involved in a conserved and simple signaling pathway.

Notch1 Transmembrane Receptor Oncogene. What is Notch1?  Transmembrane protein involved in a conserved and simple signaling pathway.
Notch1 and pre-T-cell Acute Lymphoblastic Leukemia (T-ALL) by Lindsey Wilfley.

Notch1 and pre-T-cell Acute Lymphoblastic Leukemia (T-ALL) by Lindsey Wilfley.
C-Kit and Gastrointestinal Stromal Tumors By Jessica Danielle Stewart

C-Kit and Gastrointestinal Stromal Tumors By Jessica Danielle Stewart
SMAD4/DPC4: A Tumor Suppressor James Brooks March 23 rd, 2006.

SMAD4/DPC4: A Tumor Suppressor James Brooks March 23 rd, 2006.
4.A.3 Cell Specialization Interactions between external stimuli and regulated gene expression result in specialization of cells, tissues and organs.

4.A.3 Cell Specialization Interactions between external stimuli and regulated gene expression result in specialization of cells, tissues and organs.
Genetic models Self-organization How do genetic approaches help to understand development? How can equivalent cells organize themselves into a pattern?

Genetic models Self-organization How do genetic approaches help to understand development? How can equivalent cells organize themselves into a pattern?
Genetic models Self-organization How do genetic approaches help to understand development? How can equivalent cells organize themselves into a pattern?

Genetic models Self-organization How do genetic approaches help to understand development? How can equivalent cells organize themselves into a pattern?
Transforming Growth Factor β Receptor Type II Tina Morris

Transforming Growth Factor β Receptor Type II Tina Morris
Notch1 and its role in pre T-cell Acute Lymphoblastic Leukemia (ALL) By Rebecca Goodman.

Notch1 and its role in pre T-cell Acute Lymphoblastic Leukemia (ALL) By Rebecca Goodman.
The blue light signaling pathways

The blue light signaling pathways
Organism Estimated size (in bases) Estimated gene # Average gene density/base Diploid chromosome # Human2.9 x 10 9 ~30,0001/100,00046 Rat2.8 x 10 9 ~30,0001/100,00042.

Organism Estimated size (in bases) Estimated gene # Average gene density/base Diploid chromosome # Human2.9 x 10 9 ~30,0001/100,00046 Rat2.8 x 10 9 ~30,0001/100,00042.
Retinoic Acid Receptor Alpha and Acute Promyelocytic Leukemia Nidhi Thapar April 1, 2004.

Retinoic Acid Receptor Alpha and Acute Promyelocytic Leukemia Nidhi Thapar April 1, 2004.
RET Proto- Oncogene in The Development of Thyroid Cancer: Multiple Endocrine Neoplasia Type 2 Courtney Brooks.

RET Proto- Oncogene in The Development of Thyroid Cancer: Multiple Endocrine Neoplasia Type 2 Courtney Brooks.

Similar presentations

Ads by Google