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Mekanisme Kerja Hormon dr. Susila Sastri M.Biomed Biokimia FK-Unand
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Hormone
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Struktur Kimia Hormon 1.Polipeptida Insulin Glucagon 2.Derivat asam amino (amin) Epineprin Serotonin Tyroxin 3. Steroid (derivat kolesterol) Aldosteron Cortisol Retinoic acid 4. Eicosanoid (polyunsaturated acid, (20atom C) Prostadglandin E Thromboxane A2
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Simple Intracellular & Extracelluler Signaling
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Hormon Action
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Hypophise Anterior
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Neurohormone
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GAS MOLECULE Cell Communication
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Second messenger: Small molecules synthesized in cells in response to an external signal are the second messengers, which are responsible for intracellular signal transduction: Ca 2+, DG, Cer, IP 3, cAMP, cGMP
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Receptor Receptors: specific membrane proteins, which are able to recognize and bind to corresponding ligand molecules, become activated, and transduce signal to next signaling molecules: A. Membran B. Intra Sel Glycoprotein or Lipoprotein
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Hypothalamus Anterior pituitary Posterior pituitary Thyrotropin ACTH Somatotropin LH FSH Prolactin Vasopressin Oxytocin Thyroid Adrenal Cortex Adrenal Medulla PancreasOvary Testis Muscles liver Tissues Liver, muscles Estradiol Testosterone Insulin, glucagon, somatostatin T3 Cortisol aldosterone Mammary glands Reproductive organs Epinephrine Releasing hormones Nervous Kelenjer-Hormon-Target Sel
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1. Membrane receptors
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Signal transduction mediated by membrane receptor cAMP dependent-protein kinase A pathway cGMP dependent PKG pathway Ca 2+ dependent PK pathway Tyrosine protein Kinase pathway NF-κB pathway TGF- βpathway
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Membrane Receptor
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Cyclic AMP
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Mekanisme Signal Tranduksi
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Glucagon Cyclic AMP Cyclic GMP Ca 2+ Diacylgycerol Protein substrates PK-APK-G CalmodulinPK-C Protein Ser/Thr kinases Protein substrates Multifunctional kinases Other phospholipases 1 2 3451 234 5 Tyrosine kinase IP 3 GGGG Insulin T-cell Activation Nitric oxide G protein End result is phosphorylation of one or more proteins Hormon-2 nd Massengger- Enzim
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Inositol triphosphate System PLC; phospholipase C PIP2: phosphoinositol DAG:diacylgliserol IP3:inositol triphosphat PKC: phosphokinase C
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Intracellular receptor (DNA transcription regulated receptor) Steroid Hormone, VD 3, Thyroxine Cytosolic R: glycocorticosteroid H Nuclear R: thyroxine, estrogen, androgen, progesterone
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Hormon - Receptor highly specificity highly affinity saturation reversible binding special function model
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Control of receptor activity Phosphorylation or dephosphorylation of R Phospholipid of membrane Enzyme catalyzed hydrolysis G protein regulation
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Thyroid Mechanism of Action
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Adrenaline Mechanism of action
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ACTH Mechanism of Action
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Aldosteron Mechanism of Action
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Estrogen Mechanism of Action
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Androgen Mechanism of Action
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Insulin Receptor
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Insulin Action
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Glucagon
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GH/ STH
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