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Obesity resistance and increased hepatic expression of catabolism ‐ related mRNAs in Cnot3 +/− mice by Masahiro Morita, Yuichi Oike, Takeshi Nagashima,

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Presentation on theme: "Obesity resistance and increased hepatic expression of catabolism ‐ related mRNAs in Cnot3 +/− mice by Masahiro Morita, Yuichi Oike, Takeshi Nagashima,"— Presentation transcript:

1 Obesity resistance and increased hepatic expression of catabolism ‐ related mRNAs in Cnot3 +/− mice by Masahiro Morita, Yuichi Oike, Takeshi Nagashima, Tsuyoshi Kadomatsu, Mitsuhisa Tabata, Toru Suzuki, Takahisa Nakamura, Nobuaki Yoshida, Mariko Okada, and Tadashi Yamamoto EMBO J. Volume 30(22):4678-4691 November 16, 2011 ©2011 by European Molecular Biology Organization

2 Leanness and reduced lipid content in Cnot3+/− mice. Masahiro Morita et al. EMBO J. 2011;30:4678-4691 ©2011 by European Molecular Biology Organization

3 Increased glucose homeostasis, insulin sensitivity, and metabolic rates in Cnot3+/− mice. Masahiro Morita et al. EMBO J. 2011;30:4678-4691 ©2011 by European Molecular Biology Organization

4 Resistance to diet ‐ induced obesity and related metabolic disorder in Cnot3+/− mice. Masahiro Morita et al. EMBO J. 2011;30:4678-4691 ©2011 by European Molecular Biology Organization

5 Improvement of obesity and insulin resistance in ob/ob;Cnot3+/− mice. Masahiro Morita et al. EMBO J. 2011;30:4678-4691 ©2011 by European Molecular Biology Organization

6 Deadenylase regulates genes involved in metabolism in the liver. Masahiro Morita et al. EMBO J. 2011;30:4678-4691 ©2011 by European Molecular Biology Organization

7 CNOT3 reduction affects the poly(A) tail length of mRNAs involved in lipid metabolism and growth. Masahiro Morita et al. EMBO J. 2011;30:4678-4691 ©2011 by European Molecular Biology Organization

8 Alternation of CNOT3 expression level by responding to nutrient status and identification of CNOT3 ‐ regulated mRNAs. Masahiro Morita et al. EMBO J. 2011;30:4678-4691 ©2011 by European Molecular Biology Organization


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