1. Pharmacology Tutoring for Anticonvulsants By Alaina Darby

2. Which of the following is not a type of seizure that is generated from multiple regions on both hemispheres of the brain? a.Tonic b.Myoclonic c.Complex partial d.Absence (petit mal)

3. Which of the following is not a mechanism-oriented approach for epilepsy drug development? a.GABAergic neurotransmission enhancement b.Screening tests c.Glutamate neurotransmission inhibition d.Modification of ion channels

4. Which would not be an application for surgical resection or vagus nerve stimulation treatment in epilepsy? a.Drug resistance b.Drug intolerance c.Reduction of drug dose d.Improved drug efficacy

5. Stacie has developed diplopia and ataxia after taking phenytoin. What should the doctor do? a.Adjust her dose down b.Treat the side effects c.Change her medication d.Discontinue the phenytoin

6. Amy has been experiencing absence seizures. Which of the following would be best for her to take? a.Carbamazepine b.Phenobarbital c.Clonazepam d.Tiagabine

7. Which of the following would be least likely to increase plasma concentrations of warfarin due to plasma protein binding? a.Tiagabine b.Phenytoin c.Valproate d.Carbamazepine

8. Amanda presents to the doctor with hirsutism and gingival hypertrophy. Which of the following AED’s is she taking? a.Phenytoin b.Phenobarbital c.Valproate d.Vigabatrin

9. Which of the following AED’s does not inhibit Na + channels? a.Lamotrigine b.Topiramate c.Felbamate d.Zonisamide

10. Which of the following AED’s enhances K + channel function? a.Rufinamide b.Felbamate c.Ezogabine d.Lacosamide

11. Which of the following antagonizes glutamate receptors and can be dosed once per day? a.Carbamazepine b.Perampanel c.Gabapentin d.Felbamate

12. Doug has partial seizures, liver failure, and is taking warfarin. Which of the following should he use? a.Ethosuximide b.Carbamazepine c.Valproate d.Phenytoin

13. Kara is pregnant and has generalized tonic-clonic seizures. Which of the following could she take? a.Valproate b.Phenytoin c.Topiramate d.Zonisamide

14. Samantha has started having absence seizures. Which of the following would be the drug of choice for this type of seizure? a.Ethosuximide b.Valproate c.Lamotrigine d.Clonazepam

15. Drew is anemic and has partial seizures. Which of the following would he be able to take? a.Topiramate b.Carbamazepine c.Felbamate d.Phenobarbital

16. Which of the following would be preferred in status epilepticus? a.Diazepam b.Lorazepam c.Clonazepam d.Clorazepate

17. Which of the following AED’s has no effect on the GABA receptors? a.Gabapentin b.Felbamate c.Topiramate d.Phenobarbital

18. Which of the following AED’s would not be used to treat Lennox-Gastaut syndrome? a.Lamotrigine b.Felbamate c.Lacosamide d.Rufinamide

19. Which of the following is considered a refractory drug for partial seizures due to its side effects of vision loss, blue pigmentation in skin, and bladder dysfunction? a.Vigabatrin b.Ezogabine c.Felbamate d.Topiramate

20. Sally has developed glaucoma. Which of the following AED’s was she probably taking? a.Vigabatrin b.Ezogabine c.Felbamate d.Topiramate

21. Which of the following does not cause diplopia and ataxia? a.Phenytoin b.Felbamate c.Carbamazepine d.Lamotrigine

22. Which of the following is not used as an add-on therapy? a.Pregabalin b.Perampanel c.Lacosamide d.Topiramate

23. Valerie is experiencing hair loss, fine tremors, and weight gain. Which of the following might she be taking? a.Felbamate b.Valproate c.Levetiracetam d.Vigabatrin

24. Which of the following AED’s is not thought to exert its effect by inhibiting glutamate release? a.Lamotrigine b.Gabapentin c.Perampanel d.Levetiracetam

25. Which of the following AED’s does not block sodium channels? a.Phenytoin b.Lamotrigine c.Zonisamide d.Vigabatrin

26. Which of the following should not be taken with erythromycin? a.Valproate b.Lamotrigine c.Carbamazepine d.Perampanel

27. Which of the following does not induce UGT? a.Phenytoin b.Lamotrigine c.Carbamazepine d.Phenobarbital

28. Which of the following would not increase the risk of pregnancy when taken with oral contraceptives? a.Tigabine b.Phenytoin c.Carbamazepine d.Phenobarbital

29. Which of the following does not work by increasing the levels of GABA? a.Felbamate b.Tagabine c.Vigabatrin d.Valproate

30. Which of the following does not cause problems in the eye? a.Vigabatrin b.Ezogabine c.Zonisamide d.Topimerate