1. Date of download: 7/6/2016 Copyright © The American College of Cardiology. All rights reserved. From: Externally Delivered Focused Ultrasound for Renal Denervation J Am Coll Cardiol Intv. 2016;9(12):1292-1299. doi:10.1016/j.jcin.2016.04.013 Illustration of Externally Delivered Focused Ultrasound to the Renal Artery and Surrounding Nerves After visualizing the renal artery with the diagnostic duplex ultrasound device, and tracking of the kidney, the focal therapeutic ultrasound is delivered in a robotic way (14 spots around the kidney) within a 3-min time frame. Figure Legend:

2. Date of download: 7/6/2016 Copyright © The American College of Cardiology. All rights reserved. From: Externally Delivered Focused Ultrasound for Renal Denervation J Am Coll Cardiol Intv. 2016;9(12):1292-1299. doi:10.1016/j.jcin.2016.04.013 Waves I to III Study Aggregate Office Blood Pressure Response (n = 69) CI = confidence interval; DBP = diastolic blood pressure; SBP = systolic blood pressure; SE = standard error. Figure Legend:

3. Date of download: 7/6/2016 Copyright © The American College of Cardiology. All rights reserved. From: Externally Delivered Focused Ultrasound for Renal Denervation J Am Coll Cardiol Intv. 2016;9(12):1292-1299. doi:10.1016/j.jcin.2016.04.013 Wave III Study Average Office BP Response for Patients With Noninvasive Image Guidance (n = 22) CI = confidence interval; DBP = diastolic blood pressure; SBP = systolic blood pressure; SE = standard error. Figure Legend:

4. Date of download: 7/6/2016 Copyright © The American College of Cardiology. All rights reserved. From: Externally Delivered Focused Ultrasound for Renal Denervation J Am Coll Cardiol Intv. 2016;9(12):1292-1299. doi:10.1016/j.jcin.2016.04.013 Aggregate Ambulatory Blood Pressure 6-Month Response Stratified by Baseline Ambulatory Blood Pressure Over 135, 140, 150, and 160 mm Hg CI = confidence interval; DBP = diastolic blood pressure; SBP = systolic blood pressure; SE = standard error. Figure Legend:

5. Date of download: 7/6/2016 Copyright © The American College of Cardiology. All rights reserved. From: Externally Delivered Focused Ultrasound for Renal Denervation J Am Coll Cardiol Intv. 2016;9(12):1292-1299. doi:10.1016/j.jcin.2016.04.013 Representative Optical Coherence Tomographic Image Obtained on the Treatment Day Immediately Following the Renal Denervation Treatment With the Surround Sound System and Targeting Catheter in the Wave I Study Figure Legend: