1. Coronaviruses and Noroviruses Stanley I. Martin, MD Associate Professor Division of Infectious Diseases

2. Primary objectives 1.Recognize the structure and microbial physiology of Coronaviruses and Noroviruses and integrate this information with the human pathophysiologic correlates 2.Describe physical and chemical properties of Coronaviruses and Noroviruses 3.Describe the replication of Coronaviruses and Noroviruses 4.Describe the underlying genetic mechanisms of Coronaviruses and Noroviruses 5.Recognize the molecular basis of pathogenesis of infections due to Coronaviruses and Noroviruses

3. Primary objectives 6.Describe the physiology of infections due to Coronaviruses and Noroviruses 7.Identify the normal human immune response to infections due to Coronaviruses and Noroviruses 8.Recognize the epidemiology and ecology of infections due to Coronaviruses and Noroviruses 9.Describe and differentiate the principles of laboratory diagnosis of infections due to Coronaviruses and Noroviruses 10.Describe the treatment, prevention and control of infections due to Coronaviruses and Noroviruses

4. Coronaviruses

17. Noroviruses

20. Normal small bowel mucosa Small bowel mucosa infected by norovirus

22. Norovirus outbreaks in U.S., 1994-2006

23. Diagnosis and treatment

24. Enjoy your cruise!

25. Primary reference  Medical Microbiology, 7 th Ed. Murray, Rosenthal & Pfaller; Chapter 55, pages 506 – 511