1. Downloaded from www.pharmacy123.blogfa.com

2. نور آغا ”محمدی“ سهراب عبدالله ”عطائی“ محمد اقبال محبوب الله ”دگروال“ سمیع الله ”گرده “ زبیر ”بنیادی“ عبدالمقسط ”هائد“ رامین ”شیرزی“ اجمل ”یوسفی“ خالد ”واحدی“ Downloaded from www.pharmacy123.blogfa.com

3. Introduction Definition of S.R Information & formulation Advantage Disadvantage Dosage forms Downloaded from www.pharmacy123.blogfa.com

4. Formulated to dissolve slowly and release a drug over time. ُ S.R Definition And also called: 1. Extend release 2. Time release 3. Control release Downloaded from www.pharmacy123.blogfa.com

5. استفاده از روشهای مختلف جهت باقی ماندن دوا در دستگاه عضویت به مدت طولانی تحقیقات جهت غلبه بر موانع فزیولوژیک مانند معدی معایی چرا شکل دوایی سستند ریلیزد تهیه شد؟ شناور قابل تورم Downloaded from www.pharmacy123.blogfa.com

6. Long half life (over 6h)x Not related active compound to blood levels the pharmacological effects The absorption of active compound related to active transport (SR problematic ) ُ When we can’t make SR? Downloaded from www.pharmacy123.blogfa.com

7. ُ When we can’t make SR? Long half life (over 6h)x Not related active compound to blood levels the pharmacological effects The absorption of active compound related to active transport (SR problematic) Downloaded from www.pharmacy123.blogfa.com

8. If the ac. Comp has short half life it would require a large amount to maintain a prolonged effective dose. (sometimes causes toxicity). One of administration way is SR form How it relates to your audience When we can make ُ S.R? Downloaded from www.pharmacy123.blogfa.com

9. Tablets: Dosage form of SR Downloaded from www.pharmacy123.blogfa.com

10. Capsules: Downloaded from www.pharmacy123.blogfa.com

11. Parenteral: Downloaded from www.pharmacy123.blogfa.com

12. Formulation Prednizolon….....5mg CaHPO4 …......117mg Al(OH)3 (dried).....25mg Sugar (syrup).…25mg Mg-stearate…..3/4mg Prednizolon….....5mg CaHPO4 …......117mg Al(OH)3 (dried).....25mg Sugar (syrup).…25mg Mg-stearate…..3/4mg Downloaded from www.pharmacy123.blogfa.com

13. تابلیت پردنیزولون Prednizolon……..5mg CaHPO 4 ………...117mg Al(OH) 3 (dried) ……25mg Sugar (syrup)……25mg Mg-stearate……...3/4mg Downloaded from www.pharmacy123.blogfa.com

14. طرز تهیه مخلوط نمودن سه ماده اولی گرانول نمودن (1لیتر/850گرام) عبور گرانولهای مرطوب از الک 20( °C60) خشک نمودن برای 12 ساعت عبور دوباره گرانول ها مخلوط با Mg ستیاریت بشکل tab 12 ساعت سستندریلیزد Downloaded from www.pharmacy123.blogfa.com

15. Advantages Keeping steadier level of drug in the blood. Less Side effect Taken less frequently than instant release. Downloaded from www.pharmacy123.blogfa.com

16. Disadvantage Niacin 2000-3000 mg/day increased LDL cholesterol (20-30%) but it causes gout and gastritis. S.R form of that increase It. Downloaded from www.pharmacy123.blogfa.com

17. Disadvantage In researching it cleared that: - Liver releasing x 3 - Abnormal activity of liver - For 4 weeks not used SR Niacin Downloaded from www.pharmacy123.blogfa.com

18. Sometimes SR form doesn’t have effects: Neurotics diseases Brain disiases Downloaded from www.pharmacy123.blogfa.com