1. Project #2: Hemodynamic Evaluation of Arteriovenous Fistula Sponsored by: the National Science Foundation Grant ID No: DUE-0756921 Research by: Briana Conners, Junior, Chemical Engineering and Ken Okoye, Junior, Biomedical Engineering Support by: Dr. Rupak Banerjee and Ehsan Rajabi Jaghargh, School of Mechanical Engineering College of Engineering and Applied Science; University of Cincinnati; Cincinnati, Ohio 1

2. Arteriovenous Fistula http://www.bbraun.com/cps/rde/xchg/bbraun- com/hs.xsl/6913.html AV Fistula – a surgically created connection between an artery and a vein Used to increase blood flow for dialysis In 23 – 46% of patients, the created fistulas failed to fully dilate to accommodate the increased flow. 2

3. Blood exerts a shear stress on the walls of the blood vessels as it flows through the vessel lumen. Blood vessels remodel to maintain constant wall shear stresses (WSS). If the WSS is low, smooth muscle cells are signaled to migrate to center of vessel wall. The blood vessel thickening reduces flow, inhibiting vascular access for dialysis. 3

4. Project Goals and Objectives Goals –Establish a correlation between the configuration of entry of a arteriovenus fistula and the vessel wall shear stresses. Objective –Model blood flow in four angle cases using computational fluid dynamics using data. –Derive the WSS profiles for the different AV fistula configuration –Establish the impact of difference on the intima-media thickening 4

5. Project Research Tasks Conduct literature review about topic including clinical, in vitro, in vivo, and computational research. Create models using in vivo ateriovenus fistula data. Through computational fluid dynamics, analyze blood flow in fistula with 4 varying angles of vein-artery attachment. Recommend most effective fistula configuration. 5

6. Project Timeline 6 Task Week 123456789101112 Complete Roadmap Identify Goals and Objectives Conduct Literature Survey Lab Orientation Create Models Using CFD Prepare Final Deliverables: Final Technical Paper Final PowerPoint Final Display Poster NSF Summary Report Final Report and Presentation

7. Final Deliverable Completion 7 Final Deliverables Week 123456789101112 Technical Paper 0% PowerPoint 2%3% Display Poster 0% NSF Summary 0%