1. Exercise Metabolism Chapter 4 pp 53-68

2. 1. Rest-to-Exercise: Anaerobic “anaerobic”

3. Example.... Assume standing requires 15 ATP and 0.4 liters/min of oxygen Assume running at 6 mph requires 100 ATP and 1.5 liter/min of oxygen A person can go from standing to running 6 mph in a mater of seconds. But, it takes 2-3 minutes for the oxygen requirement to go from 0.4 to 1.5 liters/min Where does the ATP needed to run 6 m.p.h come from until adequate oxygen can be supplied? 2. Rest-to-Exercise: Aerobic

4. Rest-to-Exercise: The Oxygen Deficit (aerobic) (anaerobic)

5. 3. Recovery What needs to happen in recovery? ATP-PCr system P + Cr + energy ➡ PCr Glycolysis? Lactic acid removal from muscle fiber Where does the energy comes from?

6. Lactic Acid Removal Where? Heart and Type I Muscle Fibers How? Lactic acid ➞ Pyruvic Acid Pyruvic Acid ➞ Acetyl Co-A Acetyl Co-A ➞ Krebs Cycle (aerobic system)

7. Lactate as a Fuel During Exercise Slow twitch muscle fibers Heart muscle Liver via the Cori cycle

8. E.P.O.C What does E.P.O.C. stand for What does E.P.O.C. stand for note: oxygen consumption = energy What contributes to the excess oxygen consumption? What contributes to the excess oxygen consumption? EPOC EPOC

9. (Used as a fuel) E.P.O.C.E.P.O.C.

10. 4. Prolonged Aerobic Exercise Aerobic energy requires O2 oxygen demand O2 transported via cardioplumonary system oxygen supply

11. Prolonged Aerobic Exercise Deficit: O2 supply < O2 demand Steady State Exercise O2 supply = O2 demand Heart rate? Breathing rate?

12. 5. Measurement of Aerobic Energy/Performance Maximal oxygen uptake Lactate threshold

13. 79% N 20.97% O2 0.03% CO2 79% N ~17% O2 ~4% CO2 Ventilation (Liters of air per minute) 13 Oxygen Uptake

14. 79% N ~17% O2 ~4% CO2 79% N 20.97% O2 0.03% CO2 VO2 14 Oxygen Uptake (VO2)

15. What does it measure? How is it expressed? VO2 ml/kg/min VO2 liters/min

16. Maximum Oxygen Uptake (VO2max) VO2max What is VO2max? What does it represent?

17. VO2max Values Percentile 20-29 30-3940-4950-5960+ Men 9055.152.150.649.044.2 5044.242.641.037.834.6 1034.533.031.429.926.7 Women 9049.045.842.637.834.6 5037.834.633.029.926.7 1028.426.725.121.920.3 Source: ACSM

18. * General Population, Female, Aged 20-29: 35-43 ml/kg/min * General Population, Male, Aged 20-29: 44-51 * US College Track, Male: 57.4 * College Students, Male: 44.6 * Highest Recorded Female (Cross-Country Skier): 74 * Highest Recorded Male (Cross-Country Skier): 94

19. VO2max FYI

20. FYI Bjørn Dæhlie 96 ml/kg/min Steve Prefontaine 84 ml/kg/min

21. Mitochondria (Krebs cycle & Electron Transport Chain) Acetyl-CoA 1.1. 2.2. 1.1. 2.2. Hydrogen Oxygen Lactic Acid Production What happens to pyruvate? If adequate oxygen… pyruvate to acetyl CoA hydrogen to H2O If inadequate oxygen… pyruvate and hydrogen to lactic acid What happens to lactic acid levels as the exercise intensity increases?

22. Lactate Threshold Lactate (mmols) Speed (mph) 3 4 5 6 7 8 9 10 Light to Moderate Exercise. LA removed Heavy Exercise. LA accumulates

23. Lactate Threshold The Lactate Threshold typically occurs between 50- 85% of Vo2max What is significant about the intensity level at the lactate threshold? VO2ma x 3 4 5 6 7 8 9 10 3 4 5 6 7 8 9 10 Running Speed 3 4 5 6 7 8 9 10 3 4 5 6 7 8 9 10 Running Speed

24. 7. Fuel Utilization During Exercise

25. Measuring Fuel Utilization During Exercise Respiratory exchange ratio (RER or R) R = VCO 2 / VO 2 Fat (palmitic acid) = C 16 H 32 O 2 C 16 H 32 O 2 + 23O 2 ↔ 16CO 2 + 16H 2 O + ATP R = VCO 2 /VO 2 = 16 CO 2 / 23O 2 = 0.70 Glucose = C 6 H 12 O 6 C 6 H 12 O 6 + 6O 2 ↔ 6CO 2 + 6H 2 O + ATP R = VCO 2 /VO 2 = 6 CO 2 / 6O 2 = 1.00 It takes more O2 to burn fats so the R value for fats will be lower.

26. Fuel Utilization During Exercise Carbohydrates and Fats (very little Protein) R % Fat % Carbs 0.70991 0.758317 0.806733 0.855050 0.903367 0.951783 1.00199 Low Intensity High Intensity Max. Intensity Resting

27. Fuel Utilization During Exercise Which fuel is used more as the exercise INTENSITY increases? Why the shift towards carbohydrates?

28. Fuel Utilization During Exercise What fuel is used more as the exercise DURATION increases? Why the shift towards fats? What fuel is used more as the exercise DURATION increases? Why the shift towards fats?

29. 8. Fuels for Exercise

30. Sources of Carbohydrate During Exercise Muscle glycogen Liver glycogen Total of about 2,000 kcals (1.5-2 hrs) SystemsGlycolysis Lactic acid Aerobic

31. Sources of Fat During Exercise Adipose tissue Triglycerides to fatty acids Muscle cells Total of 50,000-100,000 kcals System: aerobic

32. Protein for Energy During Exercise Skeletal muscle Amino acids and the Cori cycle Why is protein not an optimal fuel source?

33. The Glucose-Alanine Cycle

34. Gluconeogensis The Cori cycle and the Glucose-Alanine cycle What do they have in common? Gluconeogensis

35. Energy Related Fatigue Glycogen depletion Hypoglycemia