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Neuropeptide Y regulates the hematopoietic stem cell microenvironment and prevents nerve injury in the bone marrow by Min Hee Park, Hee Kyung Jin, Woo.

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Presentation on theme: "Neuropeptide Y regulates the hematopoietic stem cell microenvironment and prevents nerve injury in the bone marrow by Min Hee Park, Hee Kyung Jin, Woo."— Presentation transcript:

1 Neuropeptide Y regulates the hematopoietic stem cell microenvironment and prevents nerve injury in the bone marrow by Min Hee Park, Hee Kyung Jin, Woo ‐ Kie Min, Won Woo Lee, Jeong Eun Lee, Haruhiko Akiyama, Herbert Herzog, Grigori N Enikolopov, Edward H Schuchman, and Jae ‐ sung Bae EMBO J. Volume 34(12):1648-1660 June 12, 2015 ©2015 by European Molecular Biology Organization

2 NPY deficiency induces impairment of HSC survival in BM Min Hee Park et al. EMBO J. 2015;34:1648-1660 ©2015 by European Molecular Biology Organization

3 NPY is required for bone marrow regeneration Min Hee Park et al. EMBO J. 2015;34:1648-1660 ©2015 by European Molecular Biology Organization

4 NPY deficiency causes the reduction of SNS fibers and ECs Min Hee Park et al. EMBO J. 2015;34:1648-1660 ©2015 by European Molecular Biology Organization

5 Reduction of SNS fibers and ECs is due to p53 ‐ dependent apoptosis Min Hee Park et al. EMBO J. 2015;34:1648-1660 ©2015 by European Molecular Biology Organization

6 The NPY/Y1 receptor contributes to bone marrow microenvironment cell survival Min Hee Park et al. EMBO J. 2015;34:1648-1660 ©2015 by European Molecular Biology Organization

7 The NPY/Y1 receptor pathway in macrophages improves bone marrow injury Min Hee Park et al. EMBO J. 2015;34:1648-1660 ©2015 by European Molecular Biology Organization

8 NPY prevents cisplatin ‐ induced mouse death by restoring bone marrow dysfunction Min Hee Park et al. EMBO J. 2015;34:1648-1660 ©2015 by European Molecular Biology Organization


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