1. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Human Anatomy & Physiology, Sixth Edition Elaine N. Marieb PowerPoint ® Lecture Slides prepared by Vince Austin, University of Kentucky 23 The Digestive System

2. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Digestive System: Overview  The alimentary canal or gastrointestinal (GI) tract digests and absorbs food  Alimentary canal – mouth, pharynx, esophagus, stomach, small intestine, and large intestine  Accessory digestive organs – teeth, tongue, gallbladder, salivary glands, liver, and pancreas

3. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Digestive System: Overview Figure 23.1

4. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Digestive Process  The GI tract is a “disassembly” line  Nutrients become more available to the body in each step  There are six essential activities:  Ingestion, propulsion, and mechanical digestion  Chemical digestion, absorption, and defecation

5. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Digestive Process Figure 23.2

6. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Gastrointestinal Tract Activities  Ingestion – taking food into the digestive tract  Propulsion – swallowing and peristalsis  Peristalsis – waves of contraction and relaxation of muscles in the organ walls  Mechanical digestion – chewing, mixing, and churning food

7. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Peristalsis and Segmentation Figure 23.3

8. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Gastrointestinal Tract Activities  Chemical digestion – catabolic breakdown of food  Absorption – movement of nutrients from the GI tract to the blood or lymph  Defecation – elimination of indigestible solid wastes

9. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Histology of the Alimentary Canal  From esophagus to the anal canal the walls of the GI tract have the same four tunics  From the lumen outward they are the mucosa, submucosa, muscularis externa, and serosa  Each tunic has a predominant tissue type and a specific digestive function

10. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Histology of the Alimentary Canal Figure 23.6

11. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Salivary Glands  Produce and secrete saliva that:  Cleanses the mouth  Moistens and dissolves food chemicals  Aids in bolus formation  Contains enzymes that break down starch  Three pairs of extrinsic glands – parotid, submandibular, and sublingual

12. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Salivary Glands Figure 23.9a

13. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Deglutition (Swallowing) Figure 23.13 (a) Upper esophageal sphincter contracted (b) Upper esophageal sphincter relaxed (c) Upper esophageal sphincter contracted (e) (d) Bolus of food Uvula Bolus Relaxed muscles Tongue Pharynx Epiglottis Glottis Trachea Bolus Epiglottis Bolus of food Longitudinal muscles contract, shortening passageway ahead of bolus Gastroesophageal sphincter closed Circular muscles contract, constricting passageway and pushing bolus down Stomach Gastroesophageal sphincter open Esophagus

14. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Stomach  Chemical breakdown of proteins begins and food is converted to chyme  Function: mixing of food, secretion, little absorption -Several types of cells: -surface mucous cells - mucous neck cells - parietal cells (produce HCl) - chief cells (produce pepsinogen) - endocrine cells (gastrin)

15. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Small Intestine Function: major site of absorption, digestion Gross Anatomy:  Connects stomach with large intestine  Three parts: duodenum, jejunum, ileum  Bile duct and pancreatic duct empty into duodenum

16. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Small Intestine: Specializations to increase surface area for absorption:

17. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Small Intestine Histological Features: Mucosal epithelium: simple columnar, w/ specialized cells - absorptive cells with microvilli - goblet cells, produce mucus - granular cells (Paneth cells; protect against bacteria) - endocrine cells (gastrin, CCK, secretin)

18. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings The Large Intestine  Functions: absorption of water and salts, secretion of mucus  Gross Anatomy: ascending colon cecum appendix transverse colon haustra descending colon sigmoid colon rectum

19. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Rectum & Anal canal Rectum  Joins the sigmoid colon with the anal canal  thick muscularis layer Anal Canal  internal sphincter: thick smooth muscle  external sphincter: skeletal muscle

20. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Cephalic Phase  Excitatory events include:  Sight or thought of food  Stimulation of taste or smell receptors  Inhibitory events include:  Loss of appetite or depression  Decrease in stimulation of the parasympathetic division

21. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Gastric Phase  Excitatory events include:  Stomach distension  Activation of stretch receptors (neural activation)  Activation of chemoreceptors by peptides, caffeine, and rising pH  Release of gastrin to the blood

22. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Gastric Phase  Inhibitory events include:  A pH lower than 2  Emotional upset that overrides the parasympathetic division

23. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Intestinal Phase  Excitatory phase – low pH; partially digested food enters the duodenum and encourages gastric gland activity  Inhibitory phase – distension of duodenum, presence of fatty, acidic, or hypertonic chyme, and/or irritants in the duodenum Closes the pyloric sphincter  Releases enterogastrones that inhibit gastric secretion

24. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Release of Gastric Juice Figure 23.16

25. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Intestinal Juice  Secreted by intestinal glands in response to distension or irritation of the mucosa  Slightly alkaline and isotonic with blood plasma  Largely water, enzyme-poor, but contains mucus

26. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Liver:  The largest gland in the body  Bile leaves the liver via:  Bile ducts, which fuse into the common hepatic duct  The common hepatic duct, which fuses with the cystic duct  These two ducts form the bile duct

27. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Gallbladder and Associated Ducts Figure 23.20

28. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Liver: Microscopic Anatomy  Hepatocytes’ functions include:  Production of bile  Processing bloodborne nutrients  Storage of fat-soluble vitamins  Detoxification  Secreted bile flows between hepatocytes toward the bile ducts in the portal triads

29. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Microscopic Anatomy of the Liver Figure 23.24c, d

30. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Composition of Bile  A yellow-green, alkaline solution containing bile salts, bile pigments, cholesterol, neutral fats, phospholipids, and electrolytes  Bile salts are cholesterol derivatives that:  Emulsify fat  Facilitate fat and cholesterol absorption  Help solubilize cholesterol  Enterohepatic circulation recycles bile salts  The chief bile pigment is bilirubin, a waste product of heme

31. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings The Gallbladder  Stores and concentrates bile by absorbing its water and ions  Releases bile via the cystic duct, which flows into the bile duct

32. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Regulation of Bile Release  Acidic, fatty chyme causes the duodenum to release:  Cholecystokinin (CCK) and secretin into the bloodstream  Bile salts and secretin transported in blood stimulate the liver to produce bile

33. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Regulation of Bile Release  Cholecystokinin causes:  The gallbladder to contract  The hepatopancreatic sphincter to relax  As a result, bile enters the duodenum

34. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Regulation of Bile Release Figure 23.25

35. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Pancreas  Exocrine function  Secretes pancreatic juice which breaks down all categories of foodstuff  Acini (clusters of secretory cells) contain zymogen granules with digestive enzymes  The pancreas also has an endocrine function – release of insulin and glucagon

36. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Acinus of the Pancreas Figure 23.26a

37. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Composition and Function of Pancreatic Juice  Water solution of enzymes and electrolytes (primarily HCO 3 – )  Neutralizes acid chyme  Provides optimal environment for pancreatic enzymes  Enzymes are released in inactive form and activated in the duodenum

38. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Composition and Function of Pancreatic Juice  Examples include  Trypsinogen is activated to trypsin  Procarboxypeptidase is activated to carboxypeptidase  Active enzymes secreted  Amylase, lipases, and nucleases  These enzymes require ions or bile for optimal activity

39. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings

40. Regulation of Pancreatic Secretion  Secretin and CCK are released when fatty or acidic chyme enters the duodenum  CCK and secretin enter the bloodstream  Upon reaching the pancreas:  CCK induces the secretion of enzyme-rich pancreatic juice  Secretin causes secretion of bicarbonate-rich pancreatic juice  Vagal stimulation also causes release of pancreatic juice

41. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Regulation of Pancreatic Secretion Figure 23.28

42. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Digestion in the Small Intestine  As chyme enters the duodenum:  Carbohydrates and proteins are only partially digested  No fat digestion has taken place

43. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Digestion in the Small Intestine  Digestion continues in the small intestine  Chyme is released slowly into the duodenum  Because it is hypertonic and has low pH, mixing is required for proper digestion  Required substances needed are supplied by the liver  Virtually all nutrient absorption takes place in the small intestine

44. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Motility in the Small Intestine  After nutrients have been absorbed:  Peristalsis begins with each wave starting distal to the previous  Meal remnants, bacteria, mucosal cells, and debris are moved into the large intestine

45. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Bacterial Flora  The bacterial flora of the large intestine consist of:  Bacteria surviving the small intestine that enter the cecum and  Those entering via the anus  These bacteria:  Colonize the colon  Ferment indigestible carbohydrates  Release irritating acids and gases (flatus)  Synthesize B complex vitamins and vitamin K

46. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Functions of the Large Intestine  Other than digestion of enteric bacteria, no further digestion takes place  Vitamins, water, and electrolytes are reclaimed  Its major function is propulsion of fecal material toward the anus  Though essential for comfort, the colon is not essential for life

47. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Chemical Digestion: Carbohydrates  Absorption:  Enter the capillary bed in the villi  Transported to the liver via the hepatic portal vein  Enzymes used: salivary amylase, pancreatic amylase, and brush border enzymes

48. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Chemical Digestion: Proteins  Absorption: similar to carbohydrates  Enzymes used: pepsin in the stomach  Enzymes acting in the small intestine  Pancreatic enzymes – trypsin, chymotrypsin, and carboxypeptidase  Brush border enzymes – aminopeptidases, carboxypeptidases, and dipeptidases

49. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Chemical Digestion: Proteins Figure 23.34

50. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Chemical Digestion: Fats  Absorption: Diffusion into intestinal cells where they:  Combine with proteins and extrude chylomicrons  Enter lacteals and are transported to systemic circulation via lymph  Glycerol and short chain fatty acids are:  Absorbed into the capillary blood in villi  Transported via the hepatic portal vein  Enzymes/chemicals used: bile salts and pancreatic lipase

51. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Chemical Digestion: Fats Figure 23.35

52. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Fatty Acid Absorption Figure 23.36

53. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Chemical Digestion: Nucleic Acids  Absorbed in villi and transported to liver via hepatic portal vein  Enzymes used: pancreatic nucleases