1. Date of download: 7/8/2016 From: Narrative Review: Initial Management of Newly Diagnosed, Early-Stage Chronic Lymphocytic Leukemia Ann Intern Med. 2006;145(6):435-447. doi:10.7326/0003-4819-145-6-200609190-00007 Evaluation of lymphocytosis.Adapted from reference (24). CBC = complete blood count; CMV = cytomegalovirus; EBV = Epstein–Barr virus; HTLV = human T-cell leukemia virus; NHL = non-Hodgkin lymphoma; TB = tuberculosis. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

2. Date of download: 7/8/2016 From: Narrative Review: Initial Management of Newly Diagnosed, Early-Stage Chronic Lymphocytic Leukemia Ann Intern Med. 2006;145(6):435-447. doi:10.7326/0003-4819-145-6-200609190-00007 Use of prognostic tests to risk stratify patients with early-stage disease.FISH = fluorescent in situ hybridization; IgV H = immunoglobulin variable-region heavy chain gene. *Fever, weight loss, night sweats, and fatigue not due to another cause (see text). †If available at center. ‡Less than or equal to 2% mutated compared with germline sequence. §Although high Z-chain–associated protein kinase-70 expression may be used to characterize patients with early-stage disease as high risk in the future, this assay cannot be recommended for routine clinical use until it can be standardized and shown to have reliable intralaboratory reproducibility. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

3. Date of download: 7/8/2016 From: Narrative Review: Initial Management of Newly Diagnosed, Early-Stage Chronic Lymphocytic Leukemia Ann Intern Med. 2006;145(6):435-447. doi:10.7326/0003-4819-145-6-200609190-00007 How the authors select first-line therapy in patients with chronic lymphocytic leukemia (CLL) who require treatment and are not participating in clinical trials.Data on FR, FCR, and PCR are from references (83), (84), and (85), respectively. FCR = fludarabine, cyclophosphamide, and rituximab; FR = fludarabine and rituximab; PCR = pentostatin, cyclophosphamide, and rituximab. *Patients with poor performance status directly due to CLL rather than comorbid disease can be treated similarly to patients with performance status 0–2. †If used to treat disease-related symptoms. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians