1. 응급의학과 남연우

2. Background Mental status abnormalities Mental status abnormalities are common reason for older patients to visit the ED Patients presenting to the ED with altered require extensive work-up mental status generally require extensive work-up diagnostic uncertainty There is still diagnostic uncertainty,  further testing is required to make definitive diagnosis

3. Background older Emergency physicians can expect that older patients will make up an increasing number patients will make up an increasing number and proportion of their patients over the next 30 years organized approach Adopting an organized approach to evaluation of mental status is important

4. Objectives This article reviews This article reviews  Significance of altered mental status in older ED patients  Specific diagnoses are discussed, including delirium, stupor and coma, and dementia focus on delirium with focus on delirium.  Approach to all older patients is suggested that should result Increased clinician comfort with older patients Improved ability to communicate with other physicians lncreased quality of care Improved patient and family satisfaction

5. Background Two main components  Level of the consciousness(arousal  Level of the consciousness(arousal)  Content of the consciousness(cognition)  May help lead physician to appropriate diagnosis

6. Background Normal level of consciousness Normal level of consciousness awake and attentive  Patient who is awake and attentive  This level of arousal depends on intact reticular activating system, cerebral cortex intact reticular activating system, cerebral cortex, communication between the two and communication between the two Hyperalert or vigilant patients Hyperalert or vigilant patients Lethargic patients Lethargic patients Stupor patients Stupor patients Comatose patients Comatose patients

7. Delirium Acute, fluctuating change in cognition, Acute, fluctuating change in cognition, impaired attention and consciousness impaired attention and consciousness most serious cause The most serious cause of altered mental status seen in older ED patients 10% of ED patients over age 65 years present Most often, however, these patients are not diagnosed by the emergency physician

8. Epidemiology mortalitywith delirium The mortality associated with delirium changes depending on whether or not the diagnosis depending on whether or not the diagnosis is made in the ED (or in hospital) Kakuma found statistically significant association between delirium and mortality delirium was undetected in the ED Subjects whose delirium was undetected in the ED had a 3-month mortality of 31%, 3-month mortality of 31%, which was significantly higher delirium was detected (12%), than that of those whose delirium was detected (12%), non-delirious subjects(14%) and non-delirious subjects(14%)

9. Epidemiology mortality ratewho develop delirium The mortality rate for elders who develop delirium during hospitalization is 22% to 76%, during hospitalization is 22% to 76%, and 3-month mortality rate of delirium is 14 times Although many patients recover fully,  Prone to prolonged recoveryperiod  Prone to prolonged recovery period persistent cognitive deficits  Increased likelihood of persistent cognitive deficits

10. Diagnosis of delirium Diagnostic and Statistical Manual of Mental Disorders (DSM)-IV Lethargy (not reach level of stupor or coma) Inattention, or Psychomotor stimulation (hyperalert) First deficit to appear is generally impairment of short-term memory (three-item recall) Disorientation to time or place Perceptual disturbances (delusions, illusions, misperceptions, or hallucinations)

11. The Confusion Assessment Method (CAM) The Confusion Assessment Method Instrument The Confusion Assessment Method Instrument : 1. [Acute Onset] Is there evidence of an acute change in mental status from the patient’s baseline? 2A. [Inattention] Did the patient have difficulty focusing attention, for example, being easily distractible, or having difficulty keeping track of what was being said? 2B. (If present or abnormal) Did this behavior fluctuate during the interview, that is, tend to come and go or increase and decrease in severity? 3. [Disorganized thinking] Was the patient’s thinking disorganized or incoherent, such as rambling or irrelevant conversation, unclear or illogical flow of ideas, or unpredictable switching from subject to subject? 4. [Altered level of consciousness]. Overall, how would you rate this patient’s level of consciousness? (Alert [normal]; Vigilant [hyperalert, overly sensitive to environmental stimuli, startled very easily], Lethargic [drowsy, easily aroused]; Stupor [difficult to arouse]; Coma; [unarousable]; Uncertain) 5. [Disorientation] Was the patient disoriented at any time during the interview, such as thinking that he or she was somewhere other than the hospital, using the wrong bed, or misjudging the time of day? 6. [Memory impairment] Did the patient demonstrate any memory problems during the interview, such as inability to remember events in the hospital or difficulty remembering instructions? 7. [Perceptual disturbances] Did the patient have any evidence of perceptual disturbances, for example, hallucinations, illusions or misinterpretations (such as thinking something was moving when it was not)? 8A. [Psychomotor agitation] At any time during the interview did the patient have an unusually increased level of Motor activity such as restlessness, picking at bedclothes, tapping fingers or making frequent sudden changes of position? 8B. [Psychomotor retardation]. At any time during the interview did the patient have an unusually decreased level of motor activity such as sluggishness, staring into space, staying in one position for a long time or moving very slowly? 9. [Altered sleep-wake cycle]. Did the patient have evidence of disturbance of the sleep-wake cycle, such as excessive daytime sleepiness with insomnia at night? First described by Inouye in 1990 Operationalized the DSM-III criteria Sensitivity of 96% and a specificity of 93%. The CAM requires the presence of acute onset and fluctuating course and inattention, and either disorganized thinking or altered level of consciousness Memory impairment and disorientation are not incorporated into the CAM

12. Differential diagnosis Primary differential diagnosis Primary differential diagnosis for patients dementia who have delirium is dementia, because both may cause impaired cognition  Onset of the symptoms  Onset of the symptoms; deliriumacute in delirium the symptoms are acute, dementialonger and more subtle in dementia the onset is longer and more subtle.  Additionally, patients who have dementia generally do not have impairment in their level of consciousness

13. Differential diagnosis Primary psychiatric disorders, such as acute ‘‘pseudodelirium” psychosis ‘‘pseudodelirium” Should be made only in patients without prior history of psychiatric disease after extensive evaluation, rather than in the ED

14. Other symptoms of delirium Altered sleep–wake patterns Altered sleep–wake patterns in 60%~70% Emotional disturbances Emotional disturbances may occur and fluctuate Nonfocal neurologic deficits Nonfocal neurologic deficits  such as speech and language deficits (dysarthria, dysnomia, dysgraphia, or aphasia)

15. Other symptoms of delirium Many of physical signs and symptoms that can occur are associated with specific etiologies  Asterixis  Asterixis : hepatic and renal disease  Nystagmus and cerebellar abnormalities  Nystagmus and cerebellar abnormalities : alcohol or drug  Pupillary abnormalities  Pupillary abnormalities : drug intoxication (eg, miosis with narcotics)  Alcohol or sedative–hypnotic withdrawal : coarse tremors, tachycardia, and low-grade fever anticholinergic medications  Frequency of anticholinergic medications “anticholinergic toxidrome” (dry mouth, urinary retention, tachycardia, fever)

16. Etiology 43% 25% 18%

17. Etiology 12% Meperidine Fentanyl pathch

18. Diagnostic testing Directed at discovering the etiology Directed at discovering the etiology  Careful clinical assessment  Tailored diagnostic tests rather than shotgun approach CBC, electrolytes, BUN, creatinine, glucose, EKG Chest radiograph and urinalysis (Common infections : pneumonia & UTI ) Lumbar puncture : if sign of meningitis are present Cardiac enzymes : EKG shows new abnormalities Hepatic function tests and serum ammonia Arterial blood gas study : chronic lung disease

19. Diagnostic testing Routine use of CT of brain is not recommended  Those who have stupor, coma, or new focal neurologic findings  If no plausible etiology of the delirium, CT should be considered

20. Treatment Directed at the underlying cause of the delirium Some patients require environmetal interventions aimed at treating the symptoms  turning off the lights  bringing families to the bedside  providing with glasses or hearing aids Physical restraints should be avoided if possible

21. Treatment Pharmacologic treatment of the symptoms  antipsychotic haloperidol  antipsychotic haloperidol recommended frequently limited anticholinergic effects 0.5 to 1.0 mg orally, IM, IV can be repeated every 30 minutes  Droperidol  Droperidol also has been used more likely to cause hypotension, sedation, and extrapyramidal effects prolongation of the QT interval and arrhythmia

22. Treatment Pharmacologic treatment of the symptoms  Benzodiazepines (lorazepam)  Benzodiazepines (lorazepam) used most commonly alcohol or sedative hypnotic withdrawal or seizures risk for paradoxic central nervous system reactions

23. Disposition Delirium has many causes, potentially serious Mortality is high, especially if unrecognized Older ED patients should be admitted for evaluation unless there is single, clear, and reversible etiology of the delirium (such as intoxication from short-acting medication)

24. Tests for cognitive impairment The standard mental status screen since 1975 has been the Mini Mental Status Exam (MMSE)  comprehensive, testing orientation, registration, recall, calculation, and ability to follow commands

25. MMSE Undesirable for routine ED use  First, it is not memorized or scored easily, making use of instructions and scoring sheets  It requires intact vision, hearing, and the ability to write  Finally, it takes a median of 6 minutes and a maximum of 14 minutes to complete

26. Orientation Memory Concentration Test OMCT used in ED-based research studies Consisting of six questions  temporal orientation, counting backward from 20, saying the months in reverse order, and short-term memory, the test takes 2 to 5 minutes to perform

27. Clock-Drawing Test Evaluates many different cognitive functions, including long-term memory, concentration, and abstract thinking Although scoring is somewhat subjective, emergency physicians with only brief training in scoring on whether CDT is normal or abnormal Similar to MMSE, requires intact vision and ability to write (1)a complete circle (2)numbers correctly placed (3) one hand larger than the other (4) hands read the correct time

28. Mini-Cog Developed as brief screen for use in primary care settings Incorporates a clock-drawing test with three- item recall (such as ‘‘pencil, car, boat’’)

29. Six-Item Screener Rapid, easily remembered, and easily scored Taking a median of 1 minute to administer Can be incorporated into physical examination Unlikely to substantially increase the time to evaluate an older patient Simplicity makes it easy to remember and score without scoring sheets or pocket cards Two core components of cognition : short-term memory and orientation

30. Stupor and coma Most cases of coma (85%) are caused by systemic disease systemic disease rather than by primary CNS abnormalities, and etiologies are similar the etiologies are similar to those of delirium Substantial overlap between discussion of delirium and that of stupor or coma more rapid evaluation Require more rapid evaluation, evaluation is similar to that of delirious patients AVPU, the Glasgow Coma Scale (GCS) AVPU, the Glasgow Coma Scale (GCS)

31. Dementia gradual and progressive Characterized by the gradual and progressive development development of multiple cognitive deficits, especially memory Can be referred for evaluation as an outpatient Chronic cognitive impairment, from limiting reliability of the medical history to reducing understanding of and compliance with discharge instructions

32. General approach Mental status abnormalities are common in older emergency department patients and may be present in up to 40% of ED patients evaluate This approach should be used to evaluate mental status in all older ED patients mental status in all older ED patients, recognition of delirium is difficult because recognition of delirium is difficult and missed delirium are serious consequences of missed delirium are serious

33. General approach The 1 ST item to assess : Level of consciousness The 1 ST item to assess : Level of consciousness (which corresponds to item A of the DSM-IV-R criteria)  Normal  Normal is alert and attentive  Abnormal  Abnormal include alert and inattentive, hyperalert, lethargic, stuporous, or comatose In stupor or coma, it is important to document response to verbal and painful stimuli by AVPU scale or the GCS A.Disturbance of consciousness A.Disturbance of consciousness (ie, reduced clarity of awareness of the environment) with reduced ability to focus, sustain, or shift attention.

34. General approach  The 2 ND item assessed is cognition  Short-term memory should be tested to improve the recognition of cognitive impairment If uncertainty exists about cognitive status, the clock drawing test can be added

35. General approach If impaired consciousness or impaired cognition, evaluation of the acuity of onset evaluation of the acuity of onset of the symptoms must be investigated  Onset of symptoms is acute (hours to days), delirium should be the working diagnosis delirium should be the working diagnosis and further testing is warranted chronic and progressive If the symptoms are chronic and progressive, dementia is more likely however, dementia is more likely

36. Summary Making the diagnosis of delirium in the ED is challenging and requires systematic approach Challenge is to identify those geriatric patients acute changes who have acute changes Mortality who have delirium that is not diagnosed significantly high in the ED or in the hospital is significantly high

37. Summary Consequently the recognition of delirium is essential for provision of quality ED care Approach to older ED patients that focuses on categorizing mental status appropriately categorizing mental status impairment impairment without substantially increasing time to evaluate patient has been presented in article adoption of this approach It is hoped that adoption of this approach should result in improvement in the care of older ED patients