1. INVESTIGATOR PORTAL A TRANSLATIONAL RESEARCH KNOWLEDGE BASE DAVID HORKY COUNTRY MANAGER – CENTRAL AND EASTERN EUROPE david.horky@thomsonreuters.com SEPTEMBER 2008

2. 2 AGENDA Translational Research Investigator Portal and its Main Advantages Using the Investigator Portal Summary

3. 3 TRANSLATIONAL RESEARCH Past 10-20 years Use of findings from basic research to develop new clinical treatments for patients Information resources have lagged behind and although the available databases have embraced the information technology era, they have remained highly specific and fractionated Investigator Portal bridges these gaps, integrates data from the diverse knowledge areas and serves all scientists working in translational research

4. 4 INVESTIGATOR PORTAL TRANSLATIONAL RESEARCH Global drive to integrate diverse areas of research (‘Bench to bedside’) Increasing number of scientists crossing previously tight boundaries Need for information resource that crosses those same boundaries

5. 5 INVESTIGATOR PORTAL MULTIPLE SOURCE TYPES Congresses Journals Intellectual Property Press Releases Regulatory Agencies

6. 6 Integrated data across diverse knowledge areas Replaces multiple subscriptions INVESTIGATOR PORTAL INTEGRATED DATA

7. 7 INVESTIGATOR PORTAL INDEXED DATA Indexes actual data, not bibliographic information Reduces search time

8. 8 For controlled vocabulary indices select the Guided Search

9. 9 Enter a search term or click ‘Index’ to open controlled vocabulary

10. 10 Use Lookup and click on your search term

11. 11 Use Lookup and click on your search term

12. 12 The list of drugs & biologics that have been studied for Parkinson’s disease

13. 13 Select the bars and click ‘View Subset’ to refine your search

14. 14 List of drugs & biologics refined by ‘under active development’

15. 15 Select the ‘Launched’ bar and click ‘Subset’

16. 16 Launched drugs for Parkinson’s disease that are under active development

17. 17 Full record for Rimonabant showing structural, metabolism, scientific and marketing information

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19. SPECIFIC TARGET SEARCHING

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23. 23 Look for intellectual property records associated with mGluR5

24. 24 Patents associated with this target

25. 25 Patents associated with this target

26. 26 Click here to see full record

27. 27 Click for raw patent information data

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29. 29 INVESTIGATOR PORTAL KEY POINTS New research solution –Translational Research Search page –Integrated data Results page –Indexing data, not source Multiple data sources –Under reported research Therapeutic areas –Flexible licensing models Visualisation Trial opportunities First in class Database subscriptions Search time Relevant data Investment

30. 30 INVESTIGATOR PORTAL LICENSING OPTIONS Oncology Cardiovascular Respiratory Neurology Psychiatry Infectious Digestive Urological Diabetes AIDS Investigator Portal Annual List Price Deals closed in 2008 (-25%) 1 Therapeutic Area $9,000 $6,750 2 Areas$15,160$11,370 3 Areas$21,320$15,990 4 Areas$27,480$20,610 5 Areas$31,696$23,772 6 Areas$35,912$26,934 7 Areas$40,128$30,096 8 Areas$43,014$32,260 9 Areas$45,900$34,425 10 Areas$48,786$36,589

31. INVESTIGATOR PORTAL Thank you! DAVID HORKY COUNTRY MANAGER – CENTRAL AND EASTERN EUROPE david.horky@thomsonreuters.com