1. Activated Protein C Use In Sepsis - A Real Magic Bullet Dr. I. Krupe University Hospital Lewisham Department of Anaesthetics And Intensive Care Medicine

2. Human Activated Protein C Endogenuous protein with -antithrombotic -profibrinolytic -antiinflammatory properties

3. Our Data APC started in January 2003 38 complete courses (96 hours)until March 2005

4. 4 incomplete courses APC discontinued after 1 hour as indication was wrong 1 patient died before completion of course of pituitary gland necrosis APC discontinued due to impending surgery 1 septic patient died before completion of course of sepsis

5. 2 courses of APC in 1 patient Patient with 2 ITU admissions due to chest infections, about 4 months apart

6. mortality

7. 2003

9. 2004

11. 2005