1. Supp table 1: Gene sets differentially expressed in Angpt-1 high MDS samples No.Gene Set NameGenes 1KEGG_CELL_CYCLE cyclin-dependent kinase 1, E2F transcription factor 2, growth arrest and DNA-damage-inducible, beta, ataxia telangiectasia mutated, MAD2 mitotic arrest deficient-like 1 (yeast), cell division cycle 20 homolog (S. cerevisiae), cyclin A2, cyclin-dependent kinase inhibitor 1C (p57, Kip2), cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4), transcription factor Dp-2 (E2F dimerization partner 2), CDC14 cell division cycle 14 homolog A (S. cerevisiae) 2KEGG_LYSOSOME cathepsin B, cathepsin L1, cathepsin S, legumain, ATPase, H+ transporting, lysosomal V0 subunit a2, iduronate 2-sulfatase, cathepsin H, major facilitator superfamily domain containing 8 3KEGG_HEMATOPOIETIC_CELL_LINEAGE integrin, alpha 6, CD36 molecule (thrombospondin receptor), CD14 molecule, CD38 molecule, membrane metallo-endopeptidase, deoxynucleotidyltransferase, terminal, glycophorin A (MNS blood group) 4KEGG_GAP_JUNCTION son of sevenless homolog 1 (Drosophila), phospholipase C, beta 4, inositol 1,4,5-trisphosphate receptor, type 1; guanylate cyclase 1, soluble, alpha 3; tubulin, beta 2A class IIa; mitogen-activated protein kinase kinase 5 5KEGG_CELL_ADHESION_MOLECULES_CAMS cadherin 1, type 1, E-cadherin (epithelial); protein tyrosine phosphatase, receptor type, C;integrin, alpha 9;syndecan 2;junctional adhesion molecule 3;vascular cell adhesion molecule 1;sialophorin 6 KEGG_COMPLEMENT_AND_COAGULATION_CAS CADES complement component 1, q subcomponent, A chain; complement component 1, q subcomponent, B chain; complement component 1, q subcomponent, C chain; alpha-2-macroglobulin; plasminogen activator, urokinase receptor; tissue factor pathway inhibitor (lipoprotein- associated coagulation inhibitor) 7KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS Fc fragment of IgG, low affinity IIa, receptor (CD32); elastase, neutrophil expressed; histone cluster 1, H2ac; histone cluster 1, H2bc; histone cluster 2, H2be 8KEGG_PATHWAYS_IN_CANCER v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma); phosphatase and tensin homolog; lymphoid enhancer-binding factor 1; insulin-like growth factor 1 receptor; vascular endothelial growth factor A; TNF receptor-associated factor 5; serine/threonine kinase 4; Cas-Br-M (murine) ecotropic retroviral transforming sequence; protein kinase C, zeta 9KEGG_CHEMOKINE_SIGNALING_PATHWAY chemokine (C-X-C motif) ligand 12; chemokine (C-C motif) ligand 4; chemokine (C-C motif) ligand 8; chemokine (C-C motif) receptor 1; chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 10KEGG_PRIMARY_IMMUNODEFICIENCY immunoglobulin lambda-like polypeptide 1; recombination activating gene 1; recombination activating gene 2 11KEGG_P53_SIGNALING_PATHWAYribonucleotide reductase M2 12KEGG_FOCAL_ADHESIONprotein phosphatase 1, regulatory subunit 12A 13 KEGG_PORPHYRIN_AND_CHLOROPHYLL_METAB OLISM aminolevulinate, delta-, synthase 2; hydroxymethylbilane synthase; heme oxygenase (decycling) 1; biliverdin reductase B (flavin reductase (NADPH)) 14KEGG_OOCYTE_MEIOSISaurora kinase A 15 KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYST EM inositol polyphosphate-4-phosphatase, type II, 105kDa; synaptojanin 2 16KEGG_ECM_RECEPTOR_INTERACTIONhyaluronan-mediated motility receptor (RHAMM)