1. What Do We Know About Aging?

2. How Old Are These People?

3. Are These Animals “Old”?

4. How Has Lifespan Changed in US? Year Average life expectancy (years)

5. How Has Lifespan Changed in US? Year Average life expectancy (years)

6. How Has Lifespan Changed in US? Age class Average life expectancy(y ears)

7. US Survival Curves, 1900 http://www.fis.org/public/survivalcurves.html

8. Aging is a CHANGE in STABLE Phase of Life History Curve http://www.fis.org/public/survivalcurves.html

9. Impact of Development on Survival

10. Impact of Disease on Survival

12. Three Definitions of Aging Mortality rate – Patterns of age-stratified populations (timing and acceleration). – Demographic parameters calculated from Gompertz model of survival curves: Initial mortality rate at maturation (IMR) Gompertz rate of mortality acceleration (G) after maturation Reproductive fitness – Aging as loss of reproductive capacity. Physico-chemical-cellular – Changes of individual organisms (molecules to organ pathology)

13. What Life History Changes Are Defined As Aging? CUPID Model Age-related events are: – Cumulative – Universal – Progressive – Intrinsic – Deleterious Basis for two OTHER definitions

14. Three Definitions of Aging Mortality rate – Patterns of age-stratified populations (timing and acceleration). – Demographic parameters calculated from Gompertz model of survival curves: Initial mortality rate at maturation (IMR) Gompertz rate of mortality acceleration (G) after maturation Reproductive fitness – Aging as loss of reproductive capacity. Physico-chemical-cellular – Changes of individual organisms (molecules to organ pathology)

15. Aging is a CHANGE in STABLE Phase of Life History Curve http://www.fis.org/public/survivalcurves.html

16. Is Aging “Intrinsic” to Biological Systems?

17. Is Aging “Intrinsic” to Biological Systems? The yelloweye rockfish