1. Santina Russo, Expose GmbH, September 2013 Enhancing the Drug Discovery Cycle Services in Protein Crystallography at the Swiss Light Source BioValley Life Sciences Week 2013

2. From Crystal to Structure Protein crystals from pharmaceutical companies Diffraction experiment at the SLS Protein structures in atomic scale Ligand binding mode information for next cycle X-Rays SLS crystal detector Simulation of lense via Fourrier transformation

3. Data Collection Service testing protein crystals data collection processing and analysis support in planning of experiments The Services Structure Solution Service structure solution by various methods model building and refinement support in interpretation of the results Since 2009 The service is designed for regular users of the SLS Billing occurs by time Since 2012

4. Company Philosophy We try to fit as neatly as possible into the customers existing processes and workflow → no predefined service packages of milestones → no standardized information flow → no standardized sample containers → no standardized sample sheets Our goal: provide the best service possible for our customers → Company vs. synchrotron owned data collection services

5. Customers oversees, eg. USA or Japan: Get their crystals measured at a state of the art Synchrotron, independently of local Synchrotrons and their shutdown periods - without any travel expenses for their personnel - no travel time for their personnel - no personnel missing at home to solve structures Benefits for customers far samples sent by planedata collected by Expose data on HD or optionally transfered directly transport back home

6. Local customers, eg. Switzerland, Germany, France: Different situation: they would not suffer big travel expenses or time losses; BUT: sample shipment is fast also → time gain Benefits for customers near → process from sending crystals to seeing the structure takes only one day enabled by- fast transport of the samples - automated scripts for on-the-fly transfer of data - automated scripts for processing, structure solution and structure refinement

7. Just-in-time production → Data collection service provides a time gain → Acceleration of the structure-based drug discovery cycle → in the morning the industry crystallographers browse though the new sets of compound structures → just-in-time production 06.0012.0018.000.0006.00 crystal transportdata collection automatic data transfer one day automatic processing, structure solution, refinement

8. We attract industry users from USA, Japan → PSI sells more shifts Gained money is partly put in beamline development → results in benefit for the user community Advantages for the SLS Constant communication between us and the MX- group is useful for both sides

9. Thanks PSI Technology Transfer MX-group at the SLS Sonia Reber for management of dewar shipment Our customers near and far Santina Russo, Expose GmbH, September 2013