1. Wake-up #2 Brown eyes (B) is dominant to blue eyes (b). A blue eyed woman marries a man who is a carrier. They want to have blue eyed children. How much of a chance do they have of that happening? Bb x bb bb B b BbBbBbBb b b 50% chance

2. Karyotypes

3. Human Genetics: Karyotypes 46 TOTAL 23 homologous pairs 46 TOTAL 23 homologous pairs

4. Sex Chromosomes 2 sex chromosomes Typical Female = XX Typical Male = XY

5. Autosomes Autosomes: Any chromosome that’s not a sex chromosome 44 Autosomes 22 pairs of Autosomes

6. What is a Karyotype? Number and appearance of chromosome set

7. Understanding a Karyotype Homologous pairs Sex Chromosomes Autosomes

8. How to Read a Karyotype 1. Look for homologous pairs in autosomes

9. How to Read a Karyotype 2. Check for 2 sex chromosomes

10. Nondisjunction Failure of the chromosomes to separate properly during meiosis

11. Monosomy (Write below Monosomy in chart) Mono – One Missing a chromosome 1 instead of 2 chromosomes Gamete Zygote

12. Turners Syndrome XO-Single X chromosome

13. Turners Syndrome Symptoms Watch video linked above to see the many faces of Turners Syndrome.

14. Trisomy (Write below Monosomy in chart) Tri – Three Having an extra chromosome 3 instead of 2 chromosomes Gamete Zygote

15. Down Syndrome Aka: Trisomy 21 There is an extra 21 st chromosome

16. Trisomy 21 Symptoms Watch video linked above to learn more about Trisomy 21.

18. Klinefelters Syndrome There is an sex chromosome; XXY

19. Nondisjunction and Chromosomal Disorders Watch video

20. Analyzing Karyotypes Examine the karyotypes on the back of your notes; using your knowledge identify the following for each: a.The sex of the person b.The chromosomal disorder or normal

21. Klinefelters; Male

22. Normal Male

23. Trisomy 21; Female