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SIP, a novel ankyrin repeat containing protein, sequesters steroid receptor coactivators in the cytoplasm by Ying Zhang, Hua Zhang, Jing Liang, Wenhua.

Published byIsabella Chambers Modified over 8 years ago

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Presentation on theme: "SIP, a novel ankyrin repeat containing protein, sequesters steroid receptor coactivators in the cytoplasm by Ying Zhang, Hua Zhang, Jing Liang, Wenhua."— Presentation transcript:

1 SIP, a novel ankyrin repeat containing protein, sequesters steroid receptor coactivators in the cytoplasm by Ying Zhang, Hua Zhang, Jing Liang, Wenhua Yu, and Yongfeng Shang EMBO J. Volume 26(11):2645-2657 June 6, 2007 ©2007 by European Molecular Biology Organization

2 Cloning and characterization of SIP. (A) A schematic representation of the structure of SRC proteins and their deletions. Ying Zhang et al. EMBO J. 2007;26:2645-2657 ©2007 by European Molecular Biology Organization

3 The expression profile of SIP in human tissues and the physical interaction of SIP with SRC ‐ 1. Ying Zhang et al. EMBO J. 2007;26:2645-2657 ©2007 by European Molecular Biology Organization

4 Subcellular localization of SIP and SRC ‐ 1. Ying Zhang et al. EMBO J. 2007;26:2645-2657 ©2007 by European Molecular Biology Organization

5 The biological function of SIP. (A) The effect of SIP on ER ‐ regulated gene transcription. Ying Zhang et al. EMBO J. 2007;26:2645-2657 ©2007 by European Molecular Biology Organization

6 Estrogen ‐ induced phosphorylation of SIP by CK II. MCF ‐ 7 cells were grown in the absence of estrogen for at least 2 days and treated with 100 nM of E2 for different times, and cellular lysates were then immunoblotted with specific antibodies against total CK... Ying Zhang et al. EMBO J. 2007;26:2645-2657 ©2007 by European Molecular Biology Organization

7 The molecular mechanism involved in sequestration of SRC ‐ 1 by SIP. (A) The effect of SIP, SIP(S/A), SIP(ΔANK), and SIP(S/D) on the subcellular localization of SRC ‐ 1. pEGFP ‐ SRC ‐ 1 and FLAG ‐ tagged SIP, or SIP mutants were cotransfected into MCF ‐ 7 cells. Ying Zhang et al. EMBO J. 2007;26:2645-2657 ©2007 by European Molecular Biology Organization

8 The effect of SIP on subcellular localization of GRIP1 and AIB1. Ying Zhang et al. EMBO J. 2007;26:2645-2657 ©2007 by European Molecular Biology Organization

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