1. Urinary system part 2 w/ few modification to end part 1

2. Urine production Primary purpose is to regulate the volume & composition of blood in the process, need to excrete: all eliminated in solution; water loss is unavoidable

3. Urine production: Glomerular filtration vital 1 st step; without it: hydrostatic pressure forces water & solutes out of bloodstream into the glomerular space

4. Renal corpuscle anatomy capsular epithelium visceral epithelium mesangial cells

6. Renal corpuscle anatomy the filtration membrane is made up of

7. Urine production: Tubular reabsorption (out of tube, back to blood) proximal convoluted tubule

8. Urine production: Tubular reabsorption (out of tube, back to blood) nephron loop D: A:

9. Urine production: Tubular reabsorption or secretion (into or out of blood) distal convoluted tubule

10. Urine production : collecting system collection ducts papillary duct

11. Two kinds of nephrons cortical nephrons (~85%) juxtamedullary nephrons

12. Then what happens?

13. Histology of ureters: tubes w/ 3 layers

14. Urinary bladder trigone

15. Urinary bladder histology wall contains mucosa

16. The urethra in females in males

17. Urethral histology lining is stratified epi that varies

18. Hormone control of kidney angiotensin II (renin-angiotensin system) antidiuretic hormone (ADH) aldosterone atrial natriuretic peptide (ANP)

19. Renin-angiotensin system If glomerular pressure is low...... the juxtaglomerular complex

20. Renin-angiotensin system in peripheral capillary beds at nephron in CNS at adrenal glands net effect:

22. Antidiuretic hormone (ADH) Net effect:

24. Aldosterone Net effect:

25. Atrial natriuretic peptide (ANP) Net result

27. Hormone summary lower BP by making more urineraise BP by making less urine

28. What kidneys do to maintain pH Remember this reaction?: CO 2 + H 2 O  H 2 CO 3  H + + HCO 3 - if acidosis conditions (pH below 7.35): if alkalosis conditions (pH above 7.45):

29. Malfunction: chronic kidney disease