2. Organs of respiratory system

3. Nose: initial receiving station of inhaled air External nares nostril Vestibule small chamber that contains hair for filtration Nasal cavitybehind vestibule Nasal Conchae/ meati increase surface area for exposure to air Mucous membraneblood vessels warm air and mucous moistens air Mucous traps small particle & bacteria

4. Pharynx: chamber that extends from the back of the nasal cavity to the larynx Internal nares:posterior opening of nasal cavity Nasopharynxsuperior part of pharynx Oropharynxposterior to back of mouth Laryngopharynxbelow tongue to larynx Passage for food & air

5. Larynx: connects the pharynx and trachea (voice box) Vocal cords: production of sound by vibrations cased by air Cartilage –thyroid cartilage- Adam’s apple –Cricoid cartilage-below thyroid –Epiglottis cartilage-tongue shaped piece that covers larynx when swallowing

6. Cartilage rings –provide support for tube –C shaped, open in back –Allows for expansion of esophagus when swallowing food. Ciliated mucous membrane –move mucous that contains microorganisms & particles Trachea: tubular air duct located in front of the esophagus

7. Bronchial tree: branching of trachea that extends into the lungs Primary bronchi: right & left branches goes to lungs Bronchioles: smaller branches off the bronchus Alveolar ducts: smallest tubes that end in the alveoli

8. Alveoli: round pouches that allow for the exchange of materials -300-500 million in the lungs -Large surface area for gas exchange -Surfactant & water allow alveolus to open & close with little effort respiratory membrane: capillaries & alveoli together to allow for rapid gas exchange

9. Lungs: the bronchiole tree, capillary networks and supporting tissue Characteristics –soft spongy organs –Occupy most of thoracic cavity Apexnarrow superior portion Basebroad inferior portion next to diaphragm Rootattachments of bronchus, blood vessels and nerves

10. Lungs cont. Serous membranes surround each lung “pleurae” –Parietal pleura outer layer, lines thoracic wall & mediastinum –Visceral pleura surrounds and is firmly attached to the lung –Pleural cavity potential space between layers Contains serous fluids that lubricates membranes to reduce friction

11. Lungs cont. Divisions Lobes –right lung contains 3 lobes left has 2 ( heart) –Each gets one branch of bronchial tree –Divides further into segments, and lobules

12. Mechanisms of breathing

13. Pressure normal air pressure is 760mmHg Air moves from high to low pressure alveoli opening causes a change in air pressure 1-3 mmHg decrease allows for air to rush inward filling lungs

14. Inspiration: inhalation or breathing in Process 1.diaphragm & muscle contract 2. thoracic cavity expands 3. pleural cavity pressure drops 4. lung surface is pulled outward causing lung volume to increase 5. alveolar pressure falls below normal atmospheric pressure 6. air rushes into lungs

15. Expirations: passive process of expelling or exhaling air Process: 1.diaphragm and muscles relax 2.thoracic cavity decrease in size 3.pleural cavity pressure increases 4.alveolar pressure becomes greater than atmospheric pressure 5.air flow outward

16. Respiratory Volumes

17. Lung volumes Factor influencing –activities –Physical differences between individuals –Health Measurement –Spirometer Dry vs. wet

18. Volumes (TV) Tidal volume (500ml): amount of air moving in/out during regular breathing (IRV) Inspiratory Reserve (3100ml): max. amount of air that can be inhaled forcibly over TV (ERV) Expiratory reserve (1200ml): max amount of air that can be exhaled forcibly over TV (RV) Residual volume (1200ml): amount of air remaining in lung after forced exhale (VC) Vital capacity (4800ml): total amount of exchangeable air determined by the sum of the TV+ IRV + ERV= VC (TLC) total lung capacity (6000ml): total of air in fully inflated system VC+ RV=TLC

20. Exchange of gases

21. Partial pressure pressure gas exerts Found by multiplying air pressure by % of gas in atmosphere –N (78%), O (21%), other (1%) –Oxygen PO 2 760 mmHg x 21% = 160 mmHg

22. Diffusion Gases will diffuse independently until its partial pressure is equalized gases dissolved in plasma only affect partial pressure (not attached to hemoglobin)

23. External respiration alveoli & blood stream Always a higher partial pressure O 2 in alveoli than plasma CO 2 higher partial pressure in plasma than alveoli O 2 & CO 2 moves across the pressure gradient easily 98% binds to hemoglobin ( oxyhemoglobin) 2% in plasma High PO 2 High PCO 2

24. Internal respiration exchange between capillaries and body Partial pressure of O 2 is greater in capillaries than interstitial fluid or cells and the opposite for CO 2 CO 2 in the blood stream moves as bicarbonate (HCO 3 ), CO 2 & a small amount on RBCs

25. buffering in blood stream CO 2 +H 2 0 >>>>>>>>> H 2 CO 3 ->>> HCO 3 + H Carbonic anhydrase carbonic acid bicarbonate In lungs reverse order HCO 3 + H >>>>>>> H 2 CO 3 ->>>>>>>> CO 2 +H 2 0 Bicarbonate carbonic acid Carbonic anhydrase Removal of H ion prevents pH from changing( buffers) If excess H ion are created by increased activity your body changes breathing rate to increase removal rate

26. Control of Breathing

27. Respiratory Center medulla oblongata & pons Medullary rhythmicity center: Rhythm of breathing Pneumotaxic area: regulate breathing rate Apneustic area: inhibit expiration, work in compliment to Pneumotaxic

28. Factors affecting breathing Chemical changes in blood –Chemosensitive areas of medulla monitor CO 2, O 2 & H- –Chemoreceptors found in aorta & corotid Degree of lung stretching –Stretch receptors found in bronchiole walls –Protect from over inflation Mental state –Involuntary: Stress, fear, or pain –Voluntary control: holding breath

29. Disease Normal lung Smokers lung Heavy smoker lung