1. VIROLOGY Claude MUVUNYI M.D, Ph.D. Head of Microbiology Unit/NRL RBC

2. VIROLOGY Module: INFECTION II Definition: Study of viral structure and behavior, HOW disease occurs and WHY? Course Intent: Undergraduate students (Medicine and Pharmacy). All aspects of virology will be covered including Viruses Structure, replication and expression mechanisms, Pathogenesis and epidemiology host defenses Methods for diagnosis

3. VIROLOGY Prerequisites: Cell and Molecular Biology: This is an absolute requirement!! If you don’t have a solid understanding of cell structure and the processes of transcription and translation, drop the class now. Microbiology: Also listed as a requirement, but I’ll let it slide if you’ve had #3. Genetics: recommended, but not required Organic chemistry and biochemistry are very helpful, but not required Immunology is also helpful, but not required

4. VIROLOGY Required text: E.K. Wagner and M.J. Hewlett, "Basic Virology", 2nd Ed. Blackwell Science, 2004. Virology: Principles and Applications. 2007. Authors: Carter and Saunders (Wiley Publishing) Recommended reference texts: S.J. Flint et al., "Principles of Virology: Molecular Biology, Pathogenesis, and Control", ASM Press, 2000. Internet resources: Animations and other materials can be found at http://www.blackwellpublishing.com/Wagner/default.asp. http://www.blackwellpublishing.com/Wagner/default.asp Class notes: You will have access to all lecture material Syllabus Power points slides syllabus as hard and soft files.

5. VIROLOGY Requirement to sit for Exams: 85 % class attendance Grade Determination: The grade in this class is determined by the following: Lecture Exam (multiple choice or short answers) – 70% Presentation or Assay (TP): 30%

6. VIROLOGY Course Outcomes: At the end of the course, students should be able to: Diagram replication strategies for the major classes of viruses Explain different strategies for viral gene expression, infection patterns and pathogenesis Explain the differences between different classes of viruses Identify reliable sources of information about epidemics, emerging viruses, and vaccination programs Describe prevention and treatment strategies associated with various viral infections

7. VIROLOGY SEQUENCE OF LECTURE MATERIAL SECTION 1: Viral definition, structures and classification SECTION 2: Replication of the virus SECTION 3: Viral Pathogenesis SECTION 4: Viral diseases and Epidemiology SECTION 5: Means of viral infection diagnosis

8. You’re from Kigali? Wow! Say… You have lovely eyes Hey, everyone! We’re going to Butare VIROLOGY